Q9: Which of the following processes are decreased by ethanol consumption? Cytosol Mitochondrion A. PATHWAY 1. major pathway of ethanol metabolism NAD* NADH + H* NAD* NADH + H* in the liver CH,-CH,-OH ADH + CH,-C=O CH;-C-OH + H-O-H ALDH ETHANOL ACETALDEHYDE АСЕТАТЕ WATER B. PATHWAY 2 microsomal ethanol CYP2E1 oxidizing system (MEOS) NADPH + H* + O2 NADP* + 2H,O Excess alcohol consumption increases the NADH:NAD* ratio in the cytosol of hepatocytes.

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter24: Metabolism And Nutrition
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Q9: Which of the following processes are decreased by ethanol consumption?
Transcribed Image Text:Q9: Which of the following processes are decreased by ethanol consumption?
Cytosol
Mitochondrion
A. PATHWAY 1.
major
pathway of
ethanol
metabolism
NAD* NADH + H*
NAD* NADH + H*
in the liver CH,-CH,-OH ADH + CH,-C=O
CH;-C-OH + H-O-H
ALDH
ETHANOL
ACETALDEHYDE
АСЕТАТЕ
WATER
B. PATHWAY 2
microsomal
ethanol
CYP2E1
oxidizing
system
(MEOS)
NADPH + H* + O2
NADP* + 2H,O
Excess alcohol consumption increases the NADH:NAD* ratio in the cytosol of hepatocytes.
Transcribed Image Text:Cytosol Mitochondrion A. PATHWAY 1. major pathway of ethanol metabolism NAD* NADH + H* NAD* NADH + H* in the liver CH,-CH,-OH ADH + CH,-C=O CH;-C-OH + H-O-H ALDH ETHANOL ACETALDEHYDE АСЕТАТЕ WATER B. PATHWAY 2 microsomal ethanol CYP2E1 oxidizing system (MEOS) NADPH + H* + O2 NADP* + 2H,O Excess alcohol consumption increases the NADH:NAD* ratio in the cytosol of hepatocytes.
Expert Solution
Step 1

In the human body, three steps are involved in alcohol metabolism.

  1. Ethanol is oxidized to acetaldehyde in the first step by the alcohol dehydrogenase enzyme.
  2. In the second step, the aldehyde dehydrogenase enzyme is used to convert acetaldehyde to acetate.
  3. The acetate is converted to acetyl CoA in the third step.
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