Blue eye color allele (b) is recessive to the dominant to the black eye color allele (B). When we sequence around the locus of the blue gene from 10 pure breed species and 10 black pure breed species we notice difference in dna sequence. The black eye species have short tandem repeat (STR), which is a short DNA sequence that is repeated 6 times in the species with blue eyes, and 10 times in the species with black eyes. These repeats are only 4 cM apart from the orange gene locus. You design a PC test that distinguishes between the 6 and 10 STRs by electrophoresis. Make pedigree that will let us to identify which alleles of the blue gene was the dominant and or recessive?

Blue eye color allele (b) is recessive to the dominant to the black eye color allele (B). When we sequence around the locus of the blue gene from 10 pure breed species and 10 black pure breed species we notice difference in dna sequence. The black eye species have short tandem repeat (STR), which is a short DNA sequence that is repeated 6 times in the species with blue eyes, and 10 times in the species with black eyes. These repeats are only 4 cM apart from the orange gene locus. You design a PC test that distinguishes between the 6 and 10 STRs by electrophoresis. Make pedigree that will let us to identify which alleles of the blue gene was the dominant and or recessive?

Name: Blue eye color allele (b) is recessive to the dominant to the black ey
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Description: Blue eye color allele (b) is recessive to the dominant to the black eye color allele (B). When we sequence around the locus of the blue gene from 10 pure breed species and 10 black pure breed species we notice difference in dna sequence. The black ey

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section19.8: Genomics And Human Evolution

Problem 2GR

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Aliens with orang eye color allele (o) is recessive to the dominant black eye color allele (O). The locus of the orange gene from 10 pure breed orange eyes aliens and 10 pure breed black eyes aliens. You notice a difference in the DNA sequence linked to each allele of the orange gene and you decide to use it as a physical marker to follow recombination between this sequence linked to the orange gene. These sequences consist of short tandem repeat (STR) with two different number of repeats, each associated with one of the two orange gene alleles. a PCR test distinguishes the 10 repeat STR and the 6 repeat STR associated with the O and o alleles respectively. Using primers on each side of the STRs you can amplify by PCR this sequence and visualizing the size of the 10 repeat and 6 repeat STRs in an electrophoresis gel. You can follow the two STR sequences (10 and 6 repeats) linkage and recombination frequencies with the orange gene locus. The black eye aliens yield a PCR fragment that is…
In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. What characteristics of the pedigree rule out inheritance of a trait encoded by a gene in the mtDNA as the cause of this disorder?
In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. Explain how a mutation in a nuclear gene might lead to deletions in mtDNA.
In a study of a muscle disorder, several affected families exhibitedvision problems, muscle weakness, and deafness (M. Zeviani et al. 1990.American Journal of Human Genetics 47:904–914). Analysis of themtDNA from affected members of these families revealed that largenumbers of their mtDNA molecules possessed deletions of varyinglengths. Different members of the same family and even differentmitochondria from the same person possessed deletions of differentsizes, so the underlying defect appeared to be a tendency for the mtDNAof affected persons to have deletions. A pedigree of one of the familiesstudied is shown below. The researchers concluded that this disorder isinherited as an autosomal dominant trait, and they mapped the diseasecausinggene to a position on chromosome 10 in the nucleus.a. What characteristics of the pedigree rule out inheritance of a traitencoded by a gene in the mtDNA as the cause of this disorder?b. Explain how a mutation in a nuclear gene might lead to deletions…
If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genome.
You sample DNA from seven bighorn sheep from a population of 2,000 in the Rocky Mountains of Colorado. You sequence 10,000 basepairs from an intron in a diploid coat color locus. You think the SNP mutation rate is somewhere around 10-3 per generation for the whole locus. How many SNPs do you expect to find?
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Take a look at the α-globin and β-globin amino acid sequences. Which sequences are more similar, the α globin in humans and the α globin in horses, or the α globin in humans and the β globin in humans? Based on your answer, would you conclude that the gene duplication that gave rise to the α-globin and β-globin genes occurred before or after the divergence of humans and horses? Explain your reasoning.
DNA profiling has been used to verify pedigrees of valuable animals such as show dogs, racing greyhounds, and thoroughbred horses. However, the technology is much harder to apply in these cases than it is in forensic applications for humans. In particular, many more DNA markers must be examined in domesticated animals to stablish the identity or close familial relationship of two DNA samples. Why would you need to look at more polymorphic loci in these animals than you would in humans?
You were tasked to conduct a population genetic survey of a diploid insect population. You obtained tissue samples from 20 individuals, ran a starch gel electrophoresis, and stained the gel for lactate dehydrogenase. Below is the result of your gel electrophoresis. You found that there are three alleles and you decided to call them F, M, and S for their fast, medium, and slow mobility on the gel. please explain this in deep. 1) What is the M allele frequency in this population? A) 0.05 b) 0.25 c) 0.30 d) 0.4 e) 0.5 2)Following up the previous question, what is the observed SS genotype frequency in this population? a) 0.1 b) 0.2 3) 0.3 4) 0.4 5) 0.5