Can I get help on how to do this question? Two mutations have occurred to proteins within the glucagon signaling pathway: A) The glucagon receptor has a mutation. This mutation causes this GPCR to always have a conformation that will induce nucleotide exchange for any associated heterotrimeric G proteins, even without glucagon binding to the receptor. B) The alpha subunit of the heterotrimeric G protein has a mutation. This mutation causes the Gα arginine finger to always be in a position to properly order the catalytic residues within the Gα subunit to promote catalysis. Question: What will the effect of the Gα mutation be on Gα's function and what is the mechanistic reason for this effect?
Can I get help on how to do this question? Two mutations have occurred to proteins within the glucagon signaling pathway: A) The glucagon receptor has a mutation. This mutation causes this GPCR to always have a conformation that will induce nucleotide exchange for any associated heterotrimeric G proteins, even without glucagon binding to the receptor. B) The alpha subunit of the heterotrimeric G protein has a mutation. This mutation causes the Gα arginine finger to always be in a position to properly order the catalytic residues within the Gα subunit to promote catalysis. Question: What will the effect of the Gα mutation be on Gα's function and what is the mechanistic reason for this effect?
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...
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Can I get help on how to do this question?
Two mutations have occurred to proteins within the glucagon signaling pathway:
A) The glucagon receptor has a mutation. This mutation causes this GPCR to always have a conformation that will induce
B) The alpha subunit of the heterotrimeric G protein has a mutation. This mutation causes the Gα arginine finger to always be in a position to properly order the catalytic residues within the Gα subunit to promote catalysis.
Question: What will the effect of the Gα mutation be on Gα's function and what is the mechanistic reason for this effect?
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