Cell division cycle mutations render the mutants unable to continue the cell cycle. This phenotype creates a paradox where mutant cells must also be grown in the lab to further identify the gene and study the role of the protein. How do you think this problem can be solved?
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Cell division cycle mutations render the mutants unable to continue the cell cycle. This
identify the gene and study the role of the protein. How do you think this problem can be
solved?
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- Speculate on how the Hayflick limit may lead to genetic disorders such as progeria and Werner syndrome. How is this related to cell division?Scientists are able to isolate cells in various phases of the cell cycle. During an experiment in which Dr. Patrick McGroyn is causing cultured tumor cells to go through mitotic cell division, he isolates a group of cells that contain one and a half times more DNA than cells isolated in the G1 phase have. What phase must these cells be in? How do you know?One important biological effect of a large dose of ionizing radiation (like X-rays) is to halt cell division. How does this occur? To answer this question, state the name and role of 2 specific and important proteins involved in the process. What happens if a cell has a mutation that prevents it from halting cell division after be irradiated? Be specific and detailed. An adult human who has reached maturity will die within a few days of receiving a radiation dose large enough to stop cell division. What does that tell you about cell division? In addition, name 2 different/unique cell types that would be primarily affected.
- A cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .If you were to look at a sample of “normal” cells, what phase of the cell cycle do you think most of the cells would be in? If you were to look at a sample of cancer cells, what phase of the cell cycle do you think most of the cells would be in?The “Hayflick limit” is the number of times cells growing in tissue culture will divide before cell proliferation ceases. What experimental procedure can be employed to remove this limit?
- A scientist studying a group of somatic cells notices that when the cell cycle is complete, half of the daughter cells have no chromosomes and the other half have 92 chromosomes. In what phase of mitosis did an error most likely occur? Explain.You are working in a cell biology lab that investigates non-small cell lung cancer cells, which of these cellular features will be suggestive of senescence in the cells observed? Choose all that apply: Group of answer choices Large flattened morphology Reduced incorporation of 5-bromodeoxyuridine (in DNA replication) Increased p53 expression Decreased expression of p15INK4B"Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain
- A hypothetical poison prevents transcription factors from binding to the gene for tubulin proteins. What impact would this have on mitosis, and why?What is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations in the same genes? Explain.BPA is a chemical compound that has historically been used in the manufacture of plastic products. However, cells often mistake BPA molecules for hormones that accelerate the cell cycle. Because of this, BPA is associated with an increased risk of certain cancers.a. How might BPA interact with the cell cycle and its checkpoints?b. Why do you think that very small concentrations of BPA might have a large effect on a cell?