Several new cancer drugs inhibit the enzymes that either put acetyl groups on histones or take them off. Suppose you are a researcher combating a cancer caused by too much expression of a gene that normally codes for a proto-oncogene gene Would you develop a drug that adds or removes acetyl groups? please indicate which one you would choose and why

Several new cancer drugs inhibit the enzymes that either put acetyl groups on histones or take them off. Suppose you are a researcher combating a cancer caused by too much expression of a gene that normally codes for a proto-oncogene gene Would you develop a drug that adds or removes acetyl groups? please indicate which one you would choose and why

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 15QP: Which of the following mutations will result in cancer? a. homozygous recessive mutation in a...

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Some cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work. Do you think the cancer-causinggenes that responded to the demethylation are likely to have beenoncogenes or tumor-suppressor genes? Explain your reasoning.
Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?
In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoning
Which of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.
New drugs are being developed that decrease DNA methylation and prevent the removal of acetyl groups from histone proteins. Explain how these drugs could affect gene expression to help kill tumor cells.
New drugs are being developed that decrease DNA methylation and prevent the removal of acetyl groups from histone Explain how these drugs could affect gene expression to help kill tumor cells.
According to the histone-code hypothesis, what is one way that cell specialization occurs? a) Differential DNA methylation patterns b) Variation in enhancers in different cells c) TFII transcription factors binding to different histones in a cell-specific manner d) Differential expression of histone modifying enzymes e) Different histones are expressed in different cells
Describe the mechanism by which histone modifications are established after DNA replication and cell division. What are some things that could go wrong if modifications can't be maintained? Think about what histone modifications do to DNA and why cells maintain parts of their chromosome as heterochromatin.
Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?
Is PI3K a proto-oncogene or a tumor suppressor gene? Why?
A research study indicated that an agent in cigarette smoke caused the silencing of a tumor suppressor gene called p53. However,upon sequencing, no mutation was found in the DNA sequence for this gene. Give two possible explanations for these results.
Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop cancer. Similarly, some people who inherit mutations in the tumor-suppressor genes p53 or RB1 never develop cancer. Explain these observations.