Cells manage to synthesize a variety of seemingly thermodynamically unfavored molecules every day. Phosphorylated glucose is an example of one of these molecules. The direct phosphorylation reaction is depicted below. As indicated, the forward reaction is unfavorable with a positive standard free energy change:   glucose + phosphate⇄ glucose-6- phosphate + water                              ΔG°’ = +14 kJ/mol   Describe specifically a thermodynamically favorable route by which the cell can produce glucose-6- phosphate from glucose. Please note cells cannot change either the temperature or the pressure at which the reaction is occurring. Please help me understand by using steps. Thank you!

Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter6: Basic Clinical Chemistry
Section6.5: Blood Glucose And Hemoglobin A1c
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Cells manage to synthesize a variety of seemingly thermodynamically unfavored molecules every day. Phosphorylated glucose is an example of one of these molecules. The direct phosphorylation reaction is depicted below. As indicated, the forward reaction is unfavorable with a positive standard free energy change:

 

glucose + phosphate⇄ glucose-6- phosphate + water                              ΔG°’ = +14 kJ/mol

 

Describe specifically a thermodynamically favorable route by which the cell can produce glucose-6- phosphate from glucose. Please note cells cannot change either the temperature or the pressure at which the reaction is occurring.

Please help me understand by using steps. Thank you!

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