-CH3 H3C. CH3 Piquindone ) Complete the blank boxes by filling in the missing structures. ii) Write (by the reaction arrows) the missing reagents for Steps 3, 4 and 5. STEP 1 H3C CO2Et NaOEt, ELOH CO>Et room temp STEP 2 1. NABH4 2. base (same transformation can also be achieved with acid) H3C. `OEt steps STEP 3 H3C, reagents??? `CH3 EtO OEt STEP 4 STEP 5 H3C, H3C reagents??? NaOEt, EtOH STEP 6 Br STEP 7 reagents??? Piquindone
-CH3 H3C. CH3 Piquindone ) Complete the blank boxes by filling in the missing structures. ii) Write (by the reaction arrows) the missing reagents for Steps 3, 4 and 5. STEP 1 H3C CO2Et NaOEt, ELOH CO>Et room temp STEP 2 1. NABH4 2. base (same transformation can also be achieved with acid) H3C. `OEt steps STEP 3 H3C, reagents??? `CH3 EtO OEt STEP 4 STEP 5 H3C, H3C reagents??? NaOEt, EtOH STEP 6 Br STEP 7 reagents??? Piquindone
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter16: Synthesis Workshop 1
Section: Chapter Questions
Problem 10CTQ
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In the image is a synthesis of the dopamine D2 recpetor antagonist, Piquindone.
i) Complete the blank boxes by filling in the missing structures.
ii) Write the missing reagents for steps 3, 4, 5 and 7.
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