QUESTION 11Ciprofloxacin has a carboxylic acid group of pKa 6.09 and a secondary amine group of pKa 8.74. Using the Henderson-Hasselbalch equation, determine determine which functional groups of the molecule will beionized in the stomach (pH 1) and in the colon (pH 6). Show your calcultions. It is not necessary to calculate the degree of ionization.HNpka 8.74F`NCiprofloxcin`NCOOHpka 6.09

Answered: Ciprofloxacin has a carboxylic acid…

Macroscale and Microscale Organic Experiments

7th Edition

ISBN:9781305577190

Author:Kenneth L. Williamson, Katherine M. Masters

Publisher:Kenneth L. Williamson, Katherine M. Masters

Chapter7: Extraction

Section: Chapter Questions

Problem 8Q

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Due to the acidic nature of carboxylic acids, their level of dissociation is directly related to the pH of the solution. Under acidic conditions (low pH), carboxylic acids are almost completely undissociated and exist primarily in their protonated form ( $RCOOH$ ). Under, basic conditions (high pH), carboxylic acids become nearly completely dissociated into their deprotonated carboxylate form ( ${RCOO}^{-}$ ). Because the environment inside a living cell is an aqueous buffer with a nearly neutral pH = 7.3 (sometimes referred to as the physiological pH

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