Compare and contrast the use of SNP genotyping:(i) in the positional cloning of Mendelian diseasegenes, (ii) in direct QTL mapping, and (iii) in GWAS.

Q: Describe how it is that when a short tandem repeat (STR) genomic region is PCR-amplified you can get…

A: * PCR is known as Polymerase chain reaction , a method which is used to make billions of copies of…

Q: How can the concept ofrecombination frequency beused in genetic mapping?

A: Recombination is a process of exchange of genetic material between two different organisms.…

Q: Which genotyping approach is to be adapted (WGS, GBS or Chip) under the existing situation of poor…

A: the choice of the approach is dependent on the experiment's aim such as evolution studies,  breed…

Q: What is a molecular marker? Give two examples. Discuss why it isgenerally easier to locate and map…

A: Introduction: Molecular markers are specific DNA segments identifiable among others in the whole…

Q: What should be the ideal characteristics of a base for suppositories dosage form?  Please briefly…

A: Suppository It is administered to produce either systemic or local effect, in solid dosage form.…

Q: Describe at least five (05) different types of commercially available vectors for cloning with size…

A: Cloning vectors are small DNA parts that are stably maintained in an organism. The foreign fragment…

Q: How do you interpret Blastn results with 0 % query coverage and 100 % identity?

A: BLAST stands for basic local alignment tool which is a program and algorithm for the comparison of…

Q: What is the basis for spectrum karyotyping?

A: Answer: Introduction:  A karyotype is the method of taking picture of chromosomes and to study its…

Q: Establish relative gene positions using two-point cross data.

A: Relative positions of genes are determined by gene mapping. A gene map represents a spatial sequence…

Q: what is Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing? how would you summarize…

A: Introduction : Hardy–Weinberg Equilibrium : In The Absence Of Other Evolutionary Factors, The…

Q: How to isolate cpDNA for whole chloroplast DNA sequencing (MiSeq system)? Any universal primer or…

A: DNA sequencing is used to determine the exact arrangement of the nucleotide bases adenine (A),…

Q: How the amplification of other genomic methods such as optical mapping helps to overcome the…

A: The amplification of other genomic methods like optical mapping  has definitely improved the…

Q: What is GenBank used for?

A: The introduction of automated DNA sequencing has created the revolution in biological data…

Q: Describe step 1: hybridization of template and primer in automated sanger sequencing

A: Introduction  Sanger sequencing is also known as the “chain termination method”. It is a method for…

Q: Describe the possible ethical or biological problems associatedwith eating peanuts from an…

A: Genetic engineering is the branch of biological science that can input alteration of DNA in an…

Q: What, if any, ethical issues might arise from the widespread use of noninvasive prenatal genetic…

A: Genetic tests is a test developed to identify changes in chromosomes, genes, or proteins. The…

Q: Genotyping of few SNPs in many patients?

A: SNP's stands for Single Nucleotide Polymorphism which usually occurs due to some point mutation. Any…

Q: compare and contrast different approaches for assessing genome assemblies using assembly…

A: Genes are hereditary functional units that are made up of DNA (deoxyribonucleic acid). The genome is…

Q: Compare and contrast the mechanisms of replicative andnon-replicative transposition.

A: Transposition is a process, during which the DNA segment is transferred from one site to another in…

Q: Why is QTL mapping in human genetic diseases important?

A: Human genetic disease or hereditary disorders is an illness brought about by changes in an…

Q: Define the Single-cell sequencing (SCS) ?

A: Working of Single-cell deoxyribonucleic acid genome sequencing involves analytic one cell,…

Q: What is using somatic nuclei of transgenic adults to generate other animals with identical genomes?

A: Genomics refers to structure, function, evolution, mapping, and editing of genomes. Somatic cells…

Q: In this qPCR plot, which sample had the least abundant starting amount of DNA?

A: qPCR(Quantitative-Polymerase Chain Reaction): It is a technique applied to measure the amount of PCR…

Q: With the many high throughput experiments that are used in biomedical research, how are some ways to…

A: High-throughput screening (HTS) is a method for scientific experimentation especially used in…

Q: Maximum number of existing transgenic animals is of which animal?

A: The process of insertion of a foreign gene into the genome of an organism in order to improve its…

Q: Examine the limitations of pedigree analysis inproviding the information needed for positional…

A: Positional cloning is a method used to determine the gene mutations that lead to the development of…

Q: What is the utility of understanding the genetic basis of susceptibility to COVID-19 for medicine…

A: To date, 3p21. 31 is the only genetic region significantly associated with severe COVID-19. Having…

Q: illustrate several applications of the chi-square test pertinent to genetics.

A: A chi-square test (X2) is a statistical procedure which is used in decision making in case of…

Q: Mention the advantages and the challenges of using SNP markers in DNA typing

A: Advantages of using SNP markers in DNA typing: 1. The essential explanation given for thinking about…

Q: Discuss the role (presence and absence) of a selectable marker (selection) in cloning a recombinant…

A: Recombinant DNA molecule is defined the molecule in which an isolated DNA fragment or gene of…

Q: What is the best analysis for estimation of family sequence conservation of domains? Enlist any two…

A: A gene is the basic physical and functional unit of the heredity. Genes are composed of the DNA.…

Q: Discuss how Genome-wide association studies (GWAS) can be used to identify genetic risk loci for (a)…

A: GWAS helps in screening the genome across the databases to find the desirable results without having…

Q: What is the one main advantage of the whole-genome shotgun strategy over the hierarchical approach?

A: Genome sequencing is a vital process that helps in biological and medical analysis.

Q: Why are next generation sequencing reads determined after negative selection, while induction values…

A: Introduction :- The process of determining the primary structure of an unbranched biopolymer through…

Q: blue-white colony selection method in the recombinant colony screening

A: Blue - white screening for selection recombinat colony :- Blue - white screening is a rapid and…

Q: How do firms like 23andme utilise GWA studies when developing DTC genetic testing?

A: 23andMe is  a  Direct-to-Consumer (DTC) genetic testing company that has received marketing…

Q: Draw a simplified schematic for Heidelberg screening to identify zygotic genes.

A: Zygotic mutants P     z/+ ♀      x      z/+♂ F1    z/z           z/+    z/+   +/+

Q: Traditional Sanger sequencing has largely been replaced in recent years by next-generation and…

A: BASIC INFORMATION  Gene Sequencing  It is a process through which the arrangement of of the…

Q: Can you suggest a method to remove oil (hydrocarbon) from seeds based on your understanding of 1DNA…

A: Introduction We will answer the question in below step.

Q: describe one example of an SNP that resulted in

A: A SNP could be a variation of one nucleotide between people

Q: Explain the Detection of the sickle-cell mutation by sequencing of PCR products?

A: The disorder in which a group of red blood cells becomes sickle-shaped, it is known as sickle cell…

Q: Briefly explain how Genome Wide Association Studies (GWAS) are done. Then, using this example of a…

A: A genome-wide association study (GWAS) is a methodology utilized in hereditary qualities examination…

Q: Among all these primer pairs from Primer-Blast, which is the best to use for a PCR reaction and why?

A: The hereditary currency of an organism is the gene. The gene is present in the DNA of an organism.…

Genome annotation

The technique of linking biological information to genome sequences is termed genome annotation. Gene annotation is the method of identifying gene locations and coding sections. It helps us understand what these genes are doing in the body through establishing structural characteristics and linking them to the actions of various proteins.