Complement activation is a cascade reaction, with each component sequentially acting on others, in a similar way to the blood-clotting system. Discuss the effects that occur when peptides are generated from the activation by either the classical or the alternative pathway

Complement activation is a cascade reaction, with each component sequentially acting on others, in a similar way to the blood-clotting system. Discuss the effects that occur when peptides are generated from the activation by either the classical or the alternative pathway

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter9: Immunity And Disease

Section: Chapter Questions

Problem 2SQ: Complement proteins function in defense by _______. a. neutralizing toxins b. enhancing resident...

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Concept explainers

Immunology

Immunology is the division of science involved with the immune reactions occurring in living organisms. The organisms are accustomed to evolving internal defense mechanisms to evade the invasion of microbial pathogens. Diverse cells are connected with stimulating the immune responses, which produce inhospitable conditions to the microbes prompting their lysis and thus inhibits the multiplication of the pathogens. The immune system can distinguish the pathogens through the aid of cellular intercommunication and launch responses to destroy them.

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Complement activation is a cascade reaction, with each component sequentially acting on
others, in a similar way to the blood-clotting system. Discuss the effects that occur when
peptides are generated from the activation by either the classical or the alternative pathway

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Although homozygous deficiencies in complement regulatory proteins cause serious diseases, more subtle alterations in the balance of complement activation versus inhibition have been found to contribute to disease susceptibility. Describe the genetic evidence linking subtle alterations in complement regulatory proteins to disease susceptibility.
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