Patients with recurrent infections of Neisseria meningitidis, an extracellular bacterial pathogen that causes meningitis, were examined to determine the underlying cause of their immunodeficiency. A subset of these patients were found to have defects in complement activation on the bacterial surface, a process that for this bacterium is dominated by alternative complement activation leading to C3b deposition on the pathogen surface. When neutrophils from these patients were examined in vitro, the results, in the figure below, were obtained. Based on these data, the identity of the green neutrophil mediator in the figure below is likely to be: Complement factor B The C3 convertase Factor P (properdin) C3b
Patients with recurrent infections of Neisseria meningitidis, an extracellular bacterial pathogen that causes meningitis, were examined to determine the underlying cause of their immunodeficiency. A subset of these patients were found to have defects in complement activation on the bacterial surface, a process that for this bacterium is dominated by alternative complement activation leading to C3b deposition on the pathogen surface. When neutrophils from these patients were examined in vitro, the results, in the figure below, were obtained. Based on these data, the identity of the green neutrophil mediator in the figure below is likely to be: Complement factor B The C3 convertase Factor P (properdin) C3b
Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter18: The Cardiovascular System: Blood
Section: Chapter Questions
Problem 24RQ: The process in which antibodies attach to antigens, causing the formation of masses of linked cells,...
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Patients with recurrent infections of Neisseria meningitidis, an extracellular bacterial pathogen that causes meningitis, were examined to determine the underlying cause of their immunodeficiency. A subset of these patients were found to have defects in complement activation on the bacterial surface, a process that for this bacterium is dominated by alternative complement activation leading to C3b deposition on the pathogen surface. When neutrophils from these patients were examined in vitro, the results, in the figure below, were obtained.
Based on these data, the identity of the green neutrophil mediator in the figure below is likely to be:
- Complement factor B
- The C3 convertase
- Factor P (properdin)
- C3b
- Mannose-binding lectin (MBL)
Transcribed Image Text:Neutrophils from healthy controls
Neutrophil plus
bacteria
Activated
neutrophil
mediators relased
during neutrophil
degranulation
Neutrophils from patient
Neutrophil plus
bacteria
Activated
neutrophil
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