Complete this mechanism

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 12P
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Complete this mechanism
9:48 PM Wed Oct 13
7 87%
A drive.google.com
A Dri
Consider the following .. carbohydrates and glycolysis
BIOCHEMISTRY 337
- New
• Glycolysis: a mechanism you should know / Aldolase
3. Hydroxyl beta to the Schiff base is
deprotonated. Electrons flow into
the protonated Schiff base,
cleaving the aldol in the process.
The first product (GAP) leaves.
Prior
2. Amine reacts with carbonyl to
form protonated Schiff base.
1. Fructose-1,6-bisphosphate binds.
My D
CH,OPO
H,N-(CH,),-
CH,OPO
c=NH-(CH,),-
HO fC-H
Shar
NH,-(CH,),-
но-с-н
H-C-0-H.
H-C-OH
CH,OPO
Shar
cz0
H-C-OH
ČH,OPO?
CH2
CH2
CH2
Rece
4. Electron flow reverses out of the
5. The Schiff base is hydrolyzed
regenerating the carbonyl and
releasing the second product
(DHAP).
Starr
Schiff base and into the enamine
H-Ċ-OH
intermediate. The carbon
CH,OPO?-
Trasi
reprotonates.
Glyceraldehyde-
3-phosphate
CH,OPO
c=NH-(CH,),
CH,OPO?
Stora
TAH-(CH,),"
CH,OPO}-
C=0
HO
882.9 MB us
ČH,OH
Dihydroxyacetone
phosphate
Transcribed Image Text:9:48 PM Wed Oct 13 7 87% A drive.google.com A Dri Consider the following .. carbohydrates and glycolysis BIOCHEMISTRY 337 - New • Glycolysis: a mechanism you should know / Aldolase 3. Hydroxyl beta to the Schiff base is deprotonated. Electrons flow into the protonated Schiff base, cleaving the aldol in the process. The first product (GAP) leaves. Prior 2. Amine reacts with carbonyl to form protonated Schiff base. 1. Fructose-1,6-bisphosphate binds. My D CH,OPO H,N-(CH,),- CH,OPO c=NH-(CH,),- HO fC-H Shar NH,-(CH,),- но-с-н H-C-0-H. H-C-OH CH,OPO Shar cz0 H-C-OH ČH,OPO? CH2 CH2 CH2 Rece 4. Electron flow reverses out of the 5. The Schiff base is hydrolyzed regenerating the carbonyl and releasing the second product (DHAP). Starr Schiff base and into the enamine H-Ċ-OH intermediate. The carbon CH,OPO?- Trasi reprotonates. Glyceraldehyde- 3-phosphate CH,OPO c=NH-(CH,), CH,OPO? Stora TAH-(CH,)," CH,OPO}- C=0 HO 882.9 MB us ČH,OH Dihydroxyacetone phosphate
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