Imagine that there is a mutation in the SRP receptor that disrupts its function. What is the logical outcome of this? Select all statements below that are true.
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Q: Draw a diagram describing the adenylyl cyclase–cAMP system.
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- The receptor-associated proteins called G proteins... A. bind GTP. B. can activate or inhibit an effector protein, e.g. adenyl cyclase. C. interact with membrane-associated proteins to influence their function. D. both a and b E. a, b, and cAn enzyme-linked receptor (a) is a cytoplasmic protein (b) would not be found on plant cell surfaces (c) forms a dimer with another enzyme-linked receptor when a ligand binds to it (d) is typically an adenylyl cyclase molecule(e) typically activates ion channelsa universal feature of cell signaling receptors is that they? a. undergo a structural (shape) change when the signal molecule is bound b. are present only in the plasma membrane c. are only ion channels d. are protein kinases e. aer only nuclear receptors
- Researchers use a technique call RNA interference to knock down (i.e. not completely gone) the Bcl-2 gene in the amygdala of lab animals. What cellular response would you expect to occur? Question 1 options: A) An increase in apoptosis; many cells in the area would die B) An increase in axon regrowth after injury C) A decrease in cytochrome c levels released from the mitochondria D) A decrease in glial cell infiltration after injuryG Protein-Coupled Receptors: a) Are 7 transmembrane receptors. b) Activate heterotrimeric G proteins c) Activate small G proteins O d) A and B are both correct. e) A and C are both correct.Which of these statements about ion movement through the plasmamembrane is true?a. Movement of Na+ out of the cell requires energy (ATP).b. When Ca2+binds to proteins in ion channels, the diffusion of Na+into the cell is inhibited.c. Specific ion channels regulate the diffusion of Na+ through theplasma membrane.d. All of these are true
- Calcium ions (a) can act as second messengers (b) split calmodulin (c) are kept at higher concentration in the cytosol than in the extracellular fluid (d) are produced in the ER by protein kinases and protein phosphatases (e) typically terminate signaling cascadesScaffold proteins (a) release kinases and phosphatases into the extracellular fluid (b) bind G proteins to cell membranes (c) increase accuracy but slow signaling cascades (d) organize groups of intracellular signaling molecules into signaling complexes (e) are transcription factors found mainly in plant cellsThe binding of inositol 1,4,5-trisphosphate (IP3) to the IP3 receptor results in the release of from the endoplasmic reticulum. a) CAMP b) ATP O c) diacylglycerol d) calcium ions
- G proteins are involved wheneverA. Binding of messenger molecules to cell surface receptors triggers a target cell response.B. Binding of ligand molecules to cell surface receptors triggers activation or inhibition of enzymes,C. Binding of ligand molecules to cell surface receptors triggers synthesis of second messengers,D. Binding of ligand molecules to cell surface receptors triggers a change.E. All of the above.Compare and contrast GPCR and RTK receptors with respect to (a)structure (especially the transmembrane region), (b) activation mechanism, and (c) initial signal transduction across the membrane.EGF signals by binding to cell surface EGF receptors. Which of these observations, if true, would BEST explain EGF’s mechanism of action? A. EGF is hydrophilic and can easily diffuse through the cell membrane B. EGF is hydrophobic and can easily diffuse through the cell membrane C. EGF is hydrophilic and cannot diffuse through the cell membrane D. EGF is hydrophobic and cannot diffuse through the cell membrane