CW is a 74-year-old male patient (65kg) was recently admitted to a hospital due to severe COVID- related pneumonia. He had impaired renal function based on the lab result on the day of his hospital admission, as his serum creatinine (SCr) concentration was 3.6 mg/dL (normal range is 0.74 to 1.35 mg/dL). He was to receive vancomycin for the severe pneumonia. The normal/usual dose of vancomycin is 1 g IV every 12 hours. Using Cockcroft-Gault equation, the elimination rate constant table and the nomogram, calculate the following: a) Adjusted dose of vancomycin based on his creatinine level, while keeping the dosing frequency constant.
CW is a 74-year-old male patient (65kg) was recently admitted to a hospital due to severe COVID-
related pneumonia. He had impaired renal function based on the lab result on the day of his
hospital admission, as his serum creatinine (SCr) concentration was 3.6 mg/dL (normal range is
0.74 to 1.35 mg/dL). He was to receive vancomycin for the severe pneumonia. The normal/usual
dose of vancomycin is 1 g IV every 12 hours. Using Cockcroft-Gault equation, the elimination rate
constant table and the nomogram, calculate the following:
a) Adjusted dose of vancomycin based on his creatinine level, while keeping the dosing frequency
constant.
b) Adjusted dosing interval of vancomycin (tau) based on his creatinine level, while keeping the
dose constant.
Vancomycin:
Vancomycin is an antibiotic used to treat a variety of bacterial infections, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and other multidrug-resistant bacteria. It works by inhibiting the synthesis of bacterial cell walls. Vancomycin is usually administered intravenously, although oral formulations are available for the treatment of certain infections.
Vancomycin is generally well-tolerated, but it can cause side effects, including allergic reactions, kidney damage, and hearing loss. It is important to monitor the levels of vancomycin in the blood to ensure that they are within the therapeutic range and not too high, as this can increase the risk of toxicity.
Because of the risk of toxicity and the emergence of vancomycin-resistant strains of bacteria, vancomycin is typically reserved for serious infections that cannot be treated with other antibiotics. It is also important to use vancomycin judiciously to help prevent the development of antibiotic resistance.
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