Assume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained 2 hour after a 1- hour infusion of vancomycin) was 34 ug/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 ug/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 ug/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxs + Cminss vd c. Calculate the new dose interval d. Calculate the new dose
Assume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained 2 hour after a 1- hour infusion of vancomycin) was 34 ug/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 ug/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 ug/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxs + Cminss vd c. Calculate the new dose interval d. Calculate the new dose
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 7.2P
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Transcribed Image Text:Assume that Ali (same patient in question 1) was
prescribed vancomycin 1000 mg every 36 hours. After few days,
Steady-state vancomycin concentrations were obtained before and after
the fourth dose, and the peak concentration (obtained ½ hour after a 1-
hour infusion of vancomycin) was 34 µg/mL while the trough
concentration (obtained immediately before dosage administration) was
2.5 pg/mL. Compute a revised vancomycin dose for this patient to
provide a steady-state peak concentration of 48 ug/mL and a steady-
state trough concentration of 17 pg/mL.
a. Estimate new rate constant (Ke) and half-life (t1/2)
b. Estimate volume of distribution (Vd) using this equation Cmaxss
+ Cminss
C. Calculate the new dose interval
d. Calculate the new dose
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