Dent disease is reabsorption of filtered solutes and progressive renal failure. The following pedigree shows the pattern of inheritance for this disorder. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? From your answer to part a, give the most likely genotypes for the following ersons in the pedigree: -1: 1-2: -5: Il-8: 1-1: IlIl-3:

Dent disease is reabsorption of filtered solutes and progressive renal failure. The following pedigree shows the pattern of inheritance for this disorder. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? From your answer to part a, give the most likely genotypes for the following ersons in the pedigree: -1: 1-2: -5: Il-8: 1-1: IlIl-3:

Name: MENDELIAN MODE OF INHERITANCE AND PEDIGREE ANALYSIS1.Dent disease is
Uploaded: 2024-03-20T06:43:04.000Z
Channel: Bartleby
Description: MENDELIAN MODE OF INHERITANCE AND PEDIGREE ANALYSIS1.Dent disease is a rare disorder of the kidney in which there is impairedreabsorption of filtered solutes and progressive renal failure. The followingpedigree shows the pattern of inheritance for t

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 8QP: Analysis of Autosomal Recessive and Dominant Traits In the following pedigree, assume that the...

See similar textbooks

Similar questions

Analysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?
Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.
Analysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?
Question:- Based on your selected mode of inheritance, show the genotypes for the following individuals. [Use these symbols for alleles: if it is autosomal, then use the symbols B - dominant, b - recessive (e.g. BB, bb etc.) if it is X-Linked, then X(B) - dominant, X(b) - recessive, and Y for Y-chromosome (e.g. X(B)X(B), X(B)Y etc.) ] I-1 I-2 II-7 II-8 III-10 III-11 III-12 IV-8 IV-9
MODIFIED TRUE OR FALSE. In the following items, read each statement carefully. I. The Mendelian pattern of inheritance is a general term that refers to any pattern of inheritance in which traits do not segregate in accordance with Mendel’s lawsII. As an example, a characteristic may be controlled by one gene with two alleles, but the two alleles have a same relationship like the simple dominant-recessive relationship a. The first statement (I) is correct and the second statement (II) is wrong b. The first statement (I) is wrong and the second statement (II) is correct c. Both statements are correct d. Both statements are wrong MODIFIED TRUE OR FALSE. In the following items, read each statement carefully. I. The continuity of life from one cell to another has its foundation in the reproduction of cells by way of the cell cycle.II. The cell cycle is an orderly sequence of events in the life of a cell from the division of a single parent cell to produce…
Inheritance regarding two un+linked genes, two loci with separate alleles from the mother, and two alleles from the father that results in an organism's genotype for those specific genes. A hereditary disease exists among humans called phenylketonuria, which is an autosomal recessive mutant allele. The father is homozygous for this condition where the mother is a carrier. The father is also bow-legged and heterozygote for this trait where the mother has straight legs. a.) show parents genotype for these two traits b.) Their first child was a daughter with straight legs and phenylketonuria. What was the probability for that to occur? c.) What was the probability that her future siblings were to be a brother and a sister (no particular order of sex) who are carriers of the disease and the brother to be bow-legged whilst the sister having straight legs? d.) If adding the blood types of the parents where the father is AB and the mother to be A. What is the probability for this couple to…
Autosomal Recessive Inheritance (trait only expressed if homozygous recessive)An albino man (nn) marries a normally pigmented woman (N_) who has an albino mother. What is the chance that their children will be albino?
The accompanying pedigree is for a rare, but relativelymild, hereditary disorder of the skin.a. How is the disorder inherited? State reasons for youranswer.b. Give genotypes for as many individuals in thepedigree as possible. (Invent your own defined allelesymbols.)c. Consider the four unaffected children of parentsIII-4 and III-5. In all four-child progenies from parentsof these genotypes, what proportion is expected tocontain all unaffected children?(picture added)
Monohybrid Cross: 1) In dogs, wire hair (S) is dominant to smooth (s). a. In a cross between a homozygous wire-haired dog with a smooth haired dog what are the genotypes and phenotypes of the F1 generation? b. If a brother and sister from the F1 generation are crossed what is the expected ratio of wire-haired to smooth-haired dogs produced from this cross?
Co- Dominance1) In cattle, the alleles for red coat (R) and white coat (W) behave as the co-dominants. Both red and white hairs are produced in the heterozygote producing a coat pattern that is called "roan." a) Give the phenotypic and genotypic ratios to be expected among the offspring from a cross of two roan animals. b) What are the expected genotypic and phenotypic ratios from a cross of a roan animal and a white one?
Unpacking the Problem 44John and Martha are contemplating having children, butJohn’s brother has galactosemia (an autosomal recessivedisease) and Martha’s great-grandmother also had galactosemia. Martha has a sister who has three children, none ofwhom have galactosemia. What is the probability that Johnand Martha’s first child will have galactosemia?1. Can the problem be restated as a pedigree? If so, writeone.2. Can parts of the problem be restated by using Punnettsquares?3. Can parts of the problem be restated by using branchdiagrams?4. In the pedigree, identify a mating that illustratesMendel’s first law.5. Define all the scientific terms in the problem, and lookup any other terms about which you are uncertain.6. What assumptions need to be made in answering thisproblem?7. Which unmentioned family members must be considered? Why?8. What statistical rules might be relevant, and in whatsituations can they be applied? Do such situations existin this problem?9. What are two generalities…
Codominance in blood types. If a male with type A blood (with genotype IAi) mates with a female having type B blood (with genotype IBi), what are the phenotypic ratios for the blood types of the offspring? ___ A : ___ B : ___ AB : ____ O Suppose that one parent has type AB blood, and the blood type of the other parent is not known. Describe how a child can (or cannot) have the following blood types: Type A Type B Type AB Type O