Describe how you would prepare 1 gram of an optically inactive mixture of esomeprazole and (+)-carvone. Assume that you have optically pure carvone ([α]D = +62°) and use -142° as the specific rotation for esomeprazole.

Describe how you would prepare 1 gram of an optically inactive mixture of esomeprazole and (+)-carvone. Assume that you have optically pure carvone ([α]D = +62°) and use -142° as the specific rotation for esomeprazole.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter19: Enolate Anions And Enamines

Section19.9: Crossed Enolate Reactions Using Lda

Problem HQ: Intermediate G in Synthesis III is produced as a racemic mixture because 1. Chiral metal catalysts...

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Question

c. Describe how you would prepare 1 gram of an optically inactive mixture of esomeprazole and (+)-carvone. Assume that you have optically pure carvone ([α]D = +62°) and use -142° as the specific rotation for esomeprazole. (You might need to use some algebra to solve this.)

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