Describe optimization of lead compound with examples and explain the receptor-based classification of chemical compounds

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Describe optimization of lead compound with examples and explain the receptor-based classification of chemical compounds 

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The process in which a drug candidate is made after the starting lead compound is recognised is called “Lead optimisation”( here lead refers to ‘leading’ not the element lead). The process includes iterative rounds of synthesis and characterisation of a potential drug to build up a structure of how the activity and chemical structures are linked in terms of interaction with its targets and its metabolism.

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