Use the following table to answer the questions  Ion Extracellular Concentration (mM) Intracellular Concentration (mM) Na+ 440 50 K+ 20 400 Cl- 560 52 Ca++ 10 1     Calculate the equilibrium potential for Na+, K+, Ca++, and Cl- ions?  If the resting membrane potential is -65, give the direction of the flow of Na+, Ca++, K+, and Cl- ion.  What will happen to the Cl- equilibrium potential, if one changes the extracellular chloride concentration from 560 mM to 100 mM? Give the direction of Cl- flow.  What is the effect of addition of extracellular TTX and TEA on equilibrium potential?  If one reduced the extracellular concentration of Na+ around a neuron, what would happen to the membrane potential? If one increased the extracellular concentration of K+ around a neuron, what would happen to the membrane potential?

Chemistry: Principles and Practice
3rd Edition
ISBN:9780534420123
Author:Daniel L. Reger, Scott R. Goode, David W. Ball, Edward Mercer
Publisher:Daniel L. Reger, Scott R. Goode, David W. Ball, Edward Mercer
Chapter18: Electrochemistry
Section: Chapter Questions
Problem 18.103QE
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Use the following table to answer the questions 

Ion

Extracellular Concentration (mM)

Intracellular Concentration (mM)

Na+

440

50

K+

20

400

Cl-

560

52

Ca++

10

1

 

 

  1. Calculate the equilibrium potential for Na+, K+, Ca++, and Cl- ions? 
  2. If the resting membrane potential is -65, give the direction of the flow of Na+, Ca++, K+, and Cl- ion. 
  3. What will happen to the Cl- equilibrium potential, if one changes the extracellular chloride concentration from 560 mM to 100 mM? Give the direction of Cl- flow. 
  4. What is the effect of addition of extracellular TTX and TEA on equilibrium potential? 
  5. If one reduced the extracellular concentration of Na+ around a neuron, what would happen to the membrane potential?
  6. If one increased the extracellular concentration of K+ around a neuron, what would happen to the membrane potential? 
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