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Din Diarin wants to methylate the diphenol shown below using methyl bromide. The reaction is a simple nucleophilic substitution, and requires both phenol groups to be deprotonated by a base so that the resulting phenoxide may attack the alkyl halide and form a C-O bond. но. Base + 2 Br DMF/H20 ОН NH2 Potential bases 1) КОН 3) K2CO3 4) CSOH 5) a) Which of the potential base(s) would likely be an acceptable choice to ensure an efficient reaction under the current reaction conditions? Briefly explain your answer.

Din Diarin wants to methylate the diphenol shown below using methyl bromide. The reaction is a simple nucleophilic substitution, and requires both phenol groups to be deprotonated by a base so that the resulting phenoxide may attack the alkyl halide and form a C-O bond. но. Base + 2 Br DMF/H20 ОН NH2 Potential bases 1) КОН 3) K2CO3 4) CSOH 5) a) Which of the potential base(s) would likely be an acceptable choice to ensure an efficient reaction under the current reaction conditions? Briefly explain your answer.

Organic Chemistry: A Guided Inquiry
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter14: Elimination
Section: Chapter Questions
Problem 35CTQ
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Din Diarin wants to methylate the diphenol shown below using methyl bromide. The reaction is a simple nucleophilic substitution, and requires both phenol groups to be deprotonated by a base so that the resulting phenoxide may attack the alkyl halide and form a C-O bond. HO Base + Br DMF/H20 ОН NH2 Potential bases 1) КОН 2) 3) K2CO3 4) CSOH 5) a) Which of the potential base(s) would likely be an acceptable choice to ensure an efficient reaction under the current reaction conditions? Briefly explain your answer.
Transcribed Image Text:Din Diarin wants to methylate the diphenol shown below using methyl bromide. The reaction is a simple nucleophilic substitution, and requires both phenol groups to be deprotonated by a base so that the resulting phenoxide may attack the alkyl halide and form a C-O bond. HO Base + Br DMF/H20 ОН NH2 Potential bases 1) КОН 2) 3) K2CO3 4) CSOH 5) a) Which of the potential base(s) would likely be an acceptable choice to ensure an efficient reaction under the current reaction conditions? Briefly explain your answer.
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