The most common application of Grignard reagents is the alkylation of aldehydes and ketones. For example, 2-butanone can react with methyl magnesium bromide to generate an alcohol. i. Identify the electrophile and the nucleophile in this reaction. ii. Draw the reaction mechanism of the above reaction. iii. Give the IUPAC name of product.

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter26: Aldol And Claisen Reactions
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4. The most common application of Grignard reagents is the alkylation of aldehydes
and ketones. For example, 2-butanone can react with methyl magnesium bromide
to generate an alcohol.
i.
Identify the electrophile and the nucleophile in this reaction.
ii.
Draw the reaction mechanism of the above reaction.
iii.
Give the IUPAC name of product.
iv.
Is the product chiral or achiral? Label the R/S notation if it is chiral.
v.
If 2-pentanone is used instead of 2-butanone, is the product chiral or
achiral? Label the R/S notation if it is chiral.
Transcribed Image Text:4. The most common application of Grignard reagents is the alkylation of aldehydes and ketones. For example, 2-butanone can react with methyl magnesium bromide to generate an alcohol. i. Identify the electrophile and the nucleophile in this reaction. ii. Draw the reaction mechanism of the above reaction. iii. Give the IUPAC name of product. iv. Is the product chiral or achiral? Label the R/S notation if it is chiral. v. If 2-pentanone is used instead of 2-butanone, is the product chiral or achiral? Label the R/S notation if it is chiral.
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