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Distinguish among maternal effect genes, segmentation genes, and homeotic genes in Drosophila.
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- Explain the functional roles of maternal-effect genes, gap genes, pair-rule genes, and segment-polarity genes in Drosophila development.Compare and contrast how maternal-effect genes, gap genes, and homeotic genes affect Drosophila development.Describe the relationship between homeotic genes in Drosophila and in mice.
- The anteriorposterior axis of a Drosophila embryo is first established by certain (a) homeotic genes (b) maternal effect genes (c) segmentation genes (d) proto-oncogenes (e) pairrule genesWhat would be the most likely effect of inhibiting the translation of hunchback mRNA throughout a Drosophila embryo?Describe the appearance of a Drosophila embryo, in which the knirps gene protein-coding sequence has been replaced by lacZ, following incubation in a solution of X-gal.
- Discuss how the anterior portion of the anteroposterior axis is established in Drosophila. What aspects of oogenesis are critical in establishing this axis? What do you think would happen if the bicoid mRNA was not trapped at the anterior end but instead diffused freely throughout the oocyte?How do we know that the mutant Bar-eye phenotype in Drosophila is due to a duplicated gene region rather than to a change in the nucleotide sequence of a gene?Describe the inheritance pattern of maternal effect genes. Explainhow the maternal effect occurs at the molecular and cellular level.What are the expected functional roles of the proteins that areencoded by maternal effect genes?