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Does acetic acid associate or dissociate in water? If yes, how does it affects in determining its partition coefficient in waterether system?
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- You want to decaffeinate your coffee by extracting the caffeine out with dichloromethane (they don't do it that way anymore, but they used to). It's too late to extract the caffeine from the coffee beans, because you've already brewed yourself a 200 mL cup of coffee. Your particular brand of coffee contains 100 mg of caffeine in that 200 mL cup. The partition coefficient of caffeine in dichloromethane/water is 9.0 (it is more soluble in the dichloromethane). one extraction using 200 mL of dichloromethane; or two extractions using 100 mL of dichloromethane each. Show your work for both parts a) and b).If the solubility of a drug is 3.8g/L and in chloroform 226g/L calculate its partition coefficient to 1 decimal placeAs part of a lab exercise, your group was assigned an unknown compound X for which you had to determine its partition coefficient between an organic solvent and water. You dissolve and shake 4 grams of X in a mixture of 130 mL benzene and 100 mL of water. At the end, your group discovered that the benzene layer contained 0.5 g of X. Use the information provided to calculate for the partition coefficient. What can you say about the chemical nature of compound X?
- Naphthalene has a log Kow of 3.33. Estimate its soil-water partition coefficient normalized to organic carbon and the 95 percent confidence interval of your estimate.What are some reasons why you did not recover 100% of each of the compounds. Human error and transfer do not count in this answer *Think chemically (Hint: Partition coefficientFill in the blank. In solvent extraction, the value of partition coefficient should be ________ in order for separation to occur.
- The active ingredient in Tylenol is acetaminophen. Suppose you had a mixture of acetaminophen and sodium chloride and wanted to separate it. Acetaminophen is soluble in ethyl acetate, CH3COOEt, and slightly soluble in water. Sodium chloride, on the other hand, is water soluble. Let’s assume that the partition coefficient for acetaminophen is KD = 8 between ethyl acetate and water mixture. If we start with a salt acetaminophen mixture that contains 10 g of acetaminophen dissolved in 100 mL of water, how much acetaminophen can we extract with two extractions of ethyl acetate 20 mL each?Do each extraction separately. Calculate how much do you extract with one extraction first. Then consider how much remains in the aqueous layer and extract again.Solute A has a partition coefficient of 3 between toluene and water, with three times as much in the toluene phase. Suppose that 100 mL of a 0.010M aqueous solution of A is extracted with toluene. What fraction of A remains in the aqueous phase, if five extraction with 100 mL is performed?Chemistry A 50ml aliquot of a 0.1 M solution of a neutral drug was extracted with 2 x 5 ml ethyl acetate. The drug concentration in the combined organic layers was found to be 0.36 M. Calculate the partition coefficient for this drug under these conditions.
- A 78 mg sample of an organic compound (molar mass = 84.0 g/mol) is partitioned between 2.00 mL of water and 2.00 mL of methylene chloride. Separation and processing of the organic phase results in the isolation of 58 mg of the organic compound. Calculate the partition coefficient for the compound between methylene chloride and water (Kpmethylene chloride/water). Your answer should reflect the proper number of significant figures.You have 150 mL of 0.25 M n-propylamine and you shake this in a mixture of 90 mL of water and 50 mL of an organic solvent and let it achieve equilibrium. You removed the water layer and titrated it using 0.30 M HCl, where end point of the titration was achieved at around 42.5 mL. Calculate for the partition coefficient of n-propylamine and describe the affinity of the compound based on the value you obtain.Need HELP ASAP Calculate the partition coefficient Kd of X in hexane. Answer in 4 significant figures. Calculate the partition coefficient Kd of X in chloroform. Answer in 4 significant figures.