Draw a reaction coordinate diagram for the following mechanism. Your diagram should clearly indicate the overall Gibbs free energy of the reaction. In addition, you should clearly label the following points: (1) any reaction intermediate, (2) all transition states, (3) the substrate binding step, and (4) the product release step. Cys90 Cys99 Cys99 Asp120 Asp120 Asp120

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
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Draw a reaction coordinate diagram for the following mechanism. Your diagram should clearly indicate
the overall Gibbs free energy of the reaction. In addition, you should clearly label the following points:
(1) any reaction intermediate, (2) all transition states, (3) the substrate binding step, and (4) the
product release step.
Cys99
Cys99
Cys99
H.
Asp120
Asp120.
Asp120
Transcribed Image Text:Draw a reaction coordinate diagram for the following mechanism. Your diagram should clearly indicate the overall Gibbs free energy of the reaction. In addition, you should clearly label the following points: (1) any reaction intermediate, (2) all transition states, (3) the substrate binding step, and (4) the product release step. Cys99 Cys99 Cys99 H. Asp120 Asp120. Asp120
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