Draw mechanism arrows to show electron movements in the Bergman cycloaromatization reaction that leads to the diradical believed responsible for the DNA-cleaving action of the antitumor agent calicheamicin γ l1.

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter23: Enzymes
Section: Chapter Questions
Problem 23.91P
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Draw mechanism arrows to show electron movements in the Bergman cycloaromatization reaction that leads to the diradical believed responsible for the DNA-cleaving action of the antitumor agent calicheamicin γ l1.

 

H
ㅎ
H-
-NHCO₂Me
polysaccharide
HO
SH-
--NHCO₂Me
polysaccharide
Diradical
DNA
DNA
diradical
ㅎ
S H
H
DNA double-
strand cleavage
Diradical
-NHCO₂Me
H
polysaccharide
Transcribed Image Text:H ㅎ H- -NHCO₂Me polysaccharide HO SH- --NHCO₂Me polysaccharide Diradical DNA DNA diradical ㅎ S H H DNA double- strand cleavage Diradical -NHCO₂Me H polysaccharide
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