Solve Question (iii) only Estimate the pl of this tripeptide. The pKa values of each amino acid are given in thetable below.(ii)Amino acidpKalpKa2pKa3Glycine2.349.60Aspartic acid1.889.603.65Glutamic acid2.199.674.25(iii)Draw the predominant ion for Gly-Asp-Glu at its pl.

Please have a look on the solution:

Answered: Draw the predominant ion for…

Science

Chemistry

Draw the predominant ion for Gly-Asp-Glu at its pl.

Organic And Biological Chemistry

7th Edition

ISBN:9781305081079

Author:STOKER, H. Stephen (howard Stephen)

Publisher:STOKER, H. Stephen (howard Stephen)

Chapter9: Proteins

Section: Chapter Questions

Problem 9.58EP

See similar textbooks

Related questions

Q: Write and name all possible dipeptides from valine and phenylalanine

A: Solution- Amino acids can be defined as the organic compounds containing amino group (−NH2) and…

Q: Calculate an approximate pI for Peptide E-G-E-A

A: The chemical structure for peptide is shown below.

Q: Part a) Draw the peptide K-E-S. Part b) How can you estimate the pI of the peptide?

A: We have to predict the structure of peptide as well as the pI.

Q: nearest 0.1 charge unit) the net charge on each amino acid when tho

A: Amino acids are molecules that combine to form proteins. There is COOH and NH2 group in amino acid.

Q: In which model is it easiest to follow thepolypeptide backbone?

A: Polypeptide backbone is that when covalent linkage occurs from one amino acid to the other which has…

Q: Of the four sequences below, one can be that of a peptide, others can't. Which is the one that can…

Q: Draw the hexapeptide with correct stereochemistry and determine the isoelectric point:…

A: Given hexapeptide: Pro-Ile-Cys-Lys-Glu-Arg

Q: meso form

Q: in

A: This question is related to peptides.

Q: Most ring fusions in a steroid molecule are: Cis Parallel Trans Anti

A: Steroid molecules generally have a four fused cycloalkane rings. For example cholesterol.

Q: Estimate the pl values of the following peptides: a. Ser-lle and b. Gly-Tyr-Val.

A: The question is based on the concept of biomolecules . we have to calculate isoelectric point for…

Q: In the box below draw the tetrahedral representation of the R enantiomer of the amino acid valine,…

A: Given Amino acid = Alanine Tetrahedral representation of R enantiomer of alanine = ?

Q: Which of the following clarifications is false? Select one: to. fibroin contains AA with sparse side…

A: Fibroin is a type of protein present in silk. Structurally, it has large widely spread amino acids…

Q: Hoe many chiral carbon is Indomethacin drug and where they are located?

A: The question is based on the concept of stereochemistry. we have to identify the possible chiral…

Q: Which

A: We have to choose Correct option

Q: Question 2: draw the chair configuration of the following tetrasaccharide GaINAc1-3 Galp1-4GlcNAcp…

Q: How is attached compound related to the simple sugar D-erythrose? Is it anenantiomer, a…

A: Stereoisomers that are Mirror images of each other are enantiomer and Stereoisomers that are…

Q: What is/are the primary stabilizer(s) of a-helices? O Hydrophobic interactions between R groups and…

A: Alpha helices are stabilized primarily by hydrogen bonds between atoms in the peptide bonds.…

Q: Does lactose mutarotate? Is it a reducing sugar? Explain. Draw the two anomeric formsof lactose

A: Disaccharides are the carbohydrates that are comprised of two sugar units. Example- lactose. The…

Q: Construct the following triglycerides and give its IUPAC nomenclature: Triolein…

Q: In Hb S, a residue is replaced by a residue. histidine lysine valine

A: given, in Hb S, a ___ residue is replaced by a __ residue.

Q: Ph3P F + G C11H14

Q: -NH 'N- H,N. NH HN HN `Ph HO, HN. HN" H2N -Ph: Phenyl group, -C6H5 `NH

Q: This is a three-part question about a tripeptide. Answer all three sub-questions. The pKR of side…

Q: Identify the chemical type of each compound (2a to 2c), according to the options given in the Answer…

A: As per the bartleby expert guidelines, I am allowed to answer FIRST one question at a time. Please…

Q: which

A: There is no amino acid which you are asking

Q: covert the following the skeletal structyres into kekule structure

Q: what is the overall net charge on the peptide KKSG at pH 7.0?

Q: an be separatd using GC why can nesc two compounds separae in Ġ C and Ot by a fractional…

A: Seperating Cis and trans isomers by fractional distillation is not possible because they are having…

Q: The fibroin proteins found in silk fibers consist of large regions of ß-pleated sheets stacked one…

A: a.

Q: For the tetrapeptide, Gly-le-Gly-His give (i) the full name of the N-terminal amio acid. (it) full…

A: Please find your solution below : Amino acids are the organic compounds that are mainly composed of…

Q: Which peptides is more likely to take up on alpha-helical structure? Explain. Top:…

A: The alpha-helical structure is the right-hand helix conformation present in the secondary structure…

Q: Draw this peptide showing correct stereochemistry (hashed/wedged bonds) and please explain…

Q: A mutational change alters a polypeptide by substitutingthree adjacent prolines for three glycines.…

Q: mino acid pKal pKa2 pKa3 Glycine 2.34 9.60 Aspartic acid 1.88 9.60 3.65 Glutamic acid 2.19 9.67 4.25…

A: The question is based on the concept of amino acids. we have to draw the structure of tripeptide…

Q: Draw the structure of the following tripeptide, and label its N-terminal and Cterminal amino acids:…

A: Given, Ala–Gly–Ser

Q: In the following peptide, which amino acids would be D chirality? HO. HS NH3 ООС ZI IZ ZI

A: D chirality represents S configuration.

Q: Which peptide in below pair has side chains that exhibit predominantly van der Waals forces?…

A: Van der Waals forces are the forces that are observed in peptides which are non polar in nature or…

Q: In a typical amino acid zwitterion, the carboxylate end is neutral O attached to an amine O…

A: A zwitterion is a compound that does not have an aggregate electrical charge and is electrically…

Q: Which of the 20 amino acids feature(s) two chiral centers? On this question you are allowed to…

A: “Since you have asked multiple question, we will solve the first question for you. If you want any…

Q: which of these four amino aid& could not rotate ithe plane of plane- folarised light? NCHECHSH)(O0H…

Q: Construct the other enantiomer for following H. CH, N-C-C H. Explain why this amino acid exists as…

A: Using concept of enantiomerism and taking mirror image of given molecule.

Q: Sketch the Fischer projection of each Stereoisomer(R and S) of the monosaccharide glyceraldehyde, ,…

Q: How many peptide bonds in the following peptide are depicted as trans? H H H3C H нн N. 'N' 'N' HO, H…

A: Note : Acid and amine reacts and forms peptide bond. Here three peptide bonds are present.

Q: Alpha glucose and beta glucose both have anomeric carbons. Where would the carbon and hydrogen show…

A: Answer - These two different stereoisomers (anomers) are designated α- and β-anomers. Anomers are…

Q: option b is correct? [CLO-6] You are asked to create a peptide sequence that would require more…

A: As Cysteine contain three functional group -SH, -NH2, and -COOH. It can able to form cage-like…

Q: species has tl

A: Given: HA + NaOH -----> A- + H3O+ at point R the pH range is about 3.7 according to given in…

Q: Draw the structure of the pentapeptide Met-Pro-Ser-His-Ile at its pl

Q: Label the chiral carob atom in ciprofibrate

A: Applying concept of chiral carbon.

Concept explainers

Polymerization Kinetics

Polymerization is a chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that diverge in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes. Polymerization is generally classified into step-growth and chain polymerization. Polymers are categorized into linear polymer and cross-linked polymers that are produced either by condensation or additional polymerization.

Question

Solve Question (iii) only

Estimate the pl of this tripeptide. The pKa values of each amino acid are given in the
table below.
(ii)
Amino acid
pKal
pKa2
pKa3
Glycine
2.34
9.60
Aspartic acid
1.88
9.60
3.65
Glutamic acid
2.19
9.67
4.25
(iii)
Draw the predominant ion for Gly-Asp-Glu at its pl.

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps with 1 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

Considering the peptide structure on the image, label N-terminus and C-terminus, circle each of the peptide (amide) bonds, and provide the primary sequence of the protein using three letter abreviaciones for the amino acids
A peptide has the sequence Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side‑chain pKa glutamate 9.609.60 2.342.34 4.254.25 histidine 9.179.17 1.821.82 6.006.00 tryptophan 9.399.39 2.382.38 serine 9.159.15 2.212.21 glycine 9.609.60 2.342.34 leucine 9.609.60 2.362.36 arginine 9.049.04 2.172.17 12.4812.48 proline 10.9610.96 1.991.99 Calculate the net charge of the molecule at pH 11 and estimate the isoelectric point (pI)(pI) for this peptide.
The Arg-Gly-Asp tripeptide (RGD) is a well-known tumour targeting peptidemotif. Explain how you would synthesise H-Arg-Gly-Asp-OH, starting fromthe constituent amino acids? Explain all steps that are necessary and discuss amechanism for one side chain protection and one C terminus protection.
His-Met-Asp-Tyr-Phe-Ser within this peptide, which amino acid residue is the most hydrophobic and why?
Draw the structure of the tetrapeptide Asp-Arg-Val-Tyr. Please show the appropriate stereochemistry of the natural amino acids in the resulting peptide. Please draw all ionizable groups in their neutral form.
What trend can you suggest for the stability of proteins under varying pH
Draw Tryptophan in a peptide bond. Explain all of the bonds using valence bond theory (VBT). Next, explain where VBT fails and how molecular orbital theory is a better description of key regions of this amino acid and the peptide bonds it forms with other residues
Consider a tripeptide (a peptide that's only 3 amino acids long) composed of one molecule each of lysine, leucine, and the hypothetical amino acid lupine (which doesn't actually exist, so don't try to look it up). Lupine has an ionizable side group with a pKa of 6.3. When this tripeptide is dissolved in an aqueous solution at pH 5.0, the net charge on the molecule is +2. Give the charge on the protonated form of the lupine side group, and the charge on the deprotonated form of the lupine side group.
A protein has a number of aspartyl and gluatmyl residues, what would be the expected pI for this protein? a. Basic pI b. Neutral pI c. Cannot be determined d. Acidic pI
In a paragraph form, provide the experimental procedures in the chemical synthesis of protein that contain native serine residues by the reaction of oxazetidine-containing peptides and α-ketoacid.
Chemistry Draw this peptide showing correct stereochemistry (hashed/wedged bonds) and please explain thoroughly. N-terminus - Val - Leu - Tyr - Cys - Ala - Gly - C-terminus
What is the amino terminal residue? What is the carboxyl terminal residue? How many amino acid residues are in the peptide? The net charge of this peptide at pH 7.4 would be?