Duchenne muscular dystrophy (DMD) is caused bya recessive mutant allele of an X-linked gene calleddystrophin. Rarely, females have disease symptomsas severe as those in males hemizygous for therecessive allele. These females are heterozygous forX-autosome reciprocal translocations where the Xchromosome breakage occurred in the middle of thedystrophin gene, breaking it into two pieces.a. If it is equally likely for X chromosome inactivation to spread from either of the X chromosomeinactivation centers (XICs; see Fig. 12.15) in thecells of this patient, what proportion of her cellswould you expect to have normal function of thedystrophin gene?
Duchenne muscular dystrophy (DMD) is caused bya recessive mutant allele of an X-linked gene calleddystrophin. Rarely, females have disease symptomsas severe as those in males hemizygous for therecessive allele. These females are heterozygous forX-autosome reciprocal translocations where the Xchromosome breakage occurred in the middle of thedystrophin gene, breaking it into two pieces.a. If it is equally likely for X chromosome inactivation to spread from either of the X chromosomeinactivation centers (XICs; see Fig. 12.15) in thecells of this patient, what proportion of her cellswould you expect to have normal function of thedystrophin gene?
Human Biology (MindTap Course List)
11th Edition
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cecie Starr, Beverly McMillan
Chapter20: Chromosomes And Human Genetics
Section: Chapter Questions
Problem 2CT: Human sex chromosomes are XX for females and XY for males. a. With respect to an X-linked gene, how...
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Question
Duchenne muscular dystrophy (DMD) is caused by
a recessive mutant allele of an X-linked gene called
dystrophin. Rarely, females have disease symptoms
as severe as those in males hemizygous for the
recessive allele. These females are heterozygous for
X-autosome reciprocal translocations where the X
chromosome breakage occurred in the middle of the
dystrophin gene, breaking it into two pieces.
a. If it is equally likely for X chromosome inactivation to spread from either of the X chromosome
inactivation centers (XICs; see Fig. 12.15) in the
cells of this patient, what proportion of her cells
would you expect to have normal function of the
dystrophin gene?
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