During clinical trials it was discovered that smokers, after one to two weeks on the drug, reported that their craving for tobacco had lessened. Further sudies confirmed this finding and the drug is now marketed under the name Zyban as an aid in smoking cessation. Propose a synthesis of bupropion from benzene. ols CI From the table of reagents, select the components necessary to synthesize the given molecule and enter their letters, in the order that they are to be used without commas between, in the box, i.e. 'hiacc'. If a reaction is to be used more than once, enter its letter multiple times as necessary. Reagents Available a. CH3CH=CH2, H3PO4 b. acetyl chloride, AlCl3 c. HNO3/H₂SO4 d. 2-methylpropanoyl chloride, AlCl3 e. H₂, Pd/C f. BH3/THF g. H₂NNH₂, OH, H₂O h. OH- i. CH31 j. H₂CRO4 k. Br₂, FeBr3 I. SOCI₂ m. Cl₂, FeCl3 n. Cl₂, A o. propanoyl chloride, AICI3 p. Br₂, H+ q. t-butylamine Previous Next

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter22: Reactions Of Benzene And Its Derivatives
Section: Chapter Questions
Problem 22.59P
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During clinical trials it was discovered that smokers, after one to two weeks on the drug,
reported that their craving for tobacco had lessened. Further sudies confirmed this
finding and the drug is now marketed under the name Zyban as an aid in smoking
cessation.
Propose a synthesis of bupropion from benzene.
CI
From the table of reagents, select the components necessary to synthesize the given molecule and enter their letters, in the order that they
are to be used without commas between, in the box, i.e. 'hiacc'.
If a reaction is to be used more than once, enter its letter multiple times as necessary.
a. CH3CH=CH2, H3PO4
b. acetyl chloride, AICI3
c. HNO3/H₂SO4
d. 2-methylpropanoyl chloride, AICI 3
e. H₂, Pd/C
f. BH3/THF
Reagents Available
g. H₂NNH₂, OH, H₂O
h. OH-
i. CH31
j.
H₂CRO4
k. Br₂, FeBr3
I. SOCI₂
m. Cl₂, FeCl3
n. Cl₂, A
o. propanoyl chloride, AICI3
p. Br₂, H+
q. t-butylamine
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Transcribed Image Text:During clinical trials it was discovered that smokers, after one to two weeks on the drug, reported that their craving for tobacco had lessened. Further sudies confirmed this finding and the drug is now marketed under the name Zyban as an aid in smoking cessation. Propose a synthesis of bupropion from benzene. CI From the table of reagents, select the components necessary to synthesize the given molecule and enter their letters, in the order that they are to be used without commas between, in the box, i.e. 'hiacc'. If a reaction is to be used more than once, enter its letter multiple times as necessary. a. CH3CH=CH2, H3PO4 b. acetyl chloride, AICI3 c. HNO3/H₂SO4 d. 2-methylpropanoyl chloride, AICI 3 e. H₂, Pd/C f. BH3/THF Reagents Available g. H₂NNH₂, OH, H₂O h. OH- i. CH31 j. H₂CRO4 k. Br₂, FeBr3 I. SOCI₂ m. Cl₂, FeCl3 n. Cl₂, A o. propanoyl chloride, AICI3 p. Br₂, H+ q. t-butylamine Previous Next
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