Even experts make mistakes. Please point out the biggest mistake in the illustration below including the figure legend written by a sperm sorting guru and renowned scientist. How do you correct it?
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Even experts make mistakes. Please point out the biggest mistake in the illustration below including the figure legend written by a sperm sorting guru and renowned scientist. How do you correct it?
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- We are following the progress of human chromosome 1 during meiosis. At the end of prophase I, how many chromosomes, chromatids, and centromeres are present to ensure that chromosome 1 faithfully traverses meiosis?A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13. In discussing this discovery with a friend who is not a cytogeneticist, explain how you would describe this location, defining each term in the chromosome address 21q13.Compare meiotic anaphase I with meiotic anaphase II. Which meiotic anaphase is most similar to the mitotic anaphase?
- The chromosome constitution number of this individual is 2=6. This drawing represents: a. mitotic metaphase. b. meiotic metaphase I. c. meiotic metaphase II. d. a gamete. e. sixnonhomologous chromosomes.Humans have 46 chromosomes in each somatic cell.a. How many chromosomes does a child receive fromits father?b. How many autosomes and how many sex chromosomes are present in each somatic cell?c. How many chromosomes are present in a humanovum?d. How many sex chromosomes are present in ahuman ovum?On rare occasions, a human male is born who is somewhat feminizedcompared with other males. Microscopic examination of the cells ofone such individual revealed that he has a single Barr body in eachcell. What is the chromosomal composition of this individual?
- During oogenesis, nondisjunction of X chromosome occurred in meiosis I. If the resulting egg unites with normal sperm, what genetic disorder(s) would be produced in live-birth offspring? Explain why?On rare occasions, people are born with a condition known as uniparental disomy. It happens when an individual inherits both copies of achromosome from one parent and no copies from the other parent. Thisoccurs when two abnormal gametes happen to complement each otherto produce a diploid zygote. For example, an abnormal sperm thatlacks chromosome 15 could fertilize an egg that contains two copies ofchromosome 15. In this situation, the individual has maternal uniparental disomy 15 because both copies of chromosome 15 were inheritedfrom the mother. Alternatively, an abnormal sperm with two copies ofchromosome 15 could fertilize an egg with no copies. This is known aspaternal uniparental disomy 15. If a female is born with paternal uniparental disomy 15, would you expect her to be phenotypically normal,have Angelman syndrome (AS), or have Prader-Willi syndrome(PWS)? Explain. Would you expect her to produce normal offspring oroffspring affected with AS or PWS?In Neurospora, his2 mutants require the amino acidhistidine for growth, and lys4 mutants require theamino acid lysine. The two genes are on the samearm of the same chromosome, in the ordercentromere - his2 - lys4.A his2 mutant is mated with a lys4 mutant. Draw all ofthe possible ordered asci that could result from meioses in which the following events occurred, accountingfor the nutritional requirements for each ascospore.Ascospores without any copy of a chromosome willabort and die, turning white in the process.a. A single crossover between the centromere and his2b. A single crossover between his2 and lys4c. Nondisjunction during the first meiotic divisiond. Nondisjunction during the second meiotic divisione. A single crossover between the centromere andhis2, followed by nondisjunction during the firstmeiotic divisionf. A single crossover between his2 and lys4,followed by nondisjunction during the firstmeiotic division
- In humans, the diploid chromosome number is 46 (2N = 46). For each of the meiotic stages listedbelow, supply the correct number of chromosomes. -Meiotic Stage Chromatids at Prophase ICentromeres at Prophase IITetrads at Prophase I (pachytene)Chromatids at Telophase IlChromosomes at Metaphase IIDyads at Anaphase IOver a period of two years, a man in his early 20s receiveda series of intermittent chemotherapy and radiotherapytreatments for Hodgkin disease. During this therapy, heand his wife were unable to initiate a pregnancy. The man had aseries of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days posttreatment. How might a genetic counselor explain the time-related differences in sperm production and the appearance and subsequent disappearance of chromosomal abnormalities?A normal female is discovered with 45 chromosomes, one ofwhich exhibits a Robertsonian translocation containing most ofchromosomes 18 and 21. Discuss the possible outcomes in heroffspring when her husband contains a normal karyotype.