Explain your answer. Below is a pedigree showing the inheritançe of colorblindness inAkoto family. Colorblindness is a recessive and X-linked trait (X'). The allele for normalvision is dominant and is represented by X°.2II235II125 6IV1. What are the genotypes of the founding parents (I-1, I-2)?2. What is the percentage of the affected offspring (II)?3. What is the phenotype of III-2?4. Is the inheritance autosomal or sex-linked?

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Description: Explain your answer. Below is a pedigree showing the inheritançe of colorblindness inAkoto family. Colorblindness is a recessive and X-linked trait (X'). The allele for normalvision is dominant and is represented by X°.2II235II125 6IV1. What are the

Colour blindness is a color vision deficiency, and a reduced ability of not distinguishing between…

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Explain your answer. Below is a pedigree showing the inheritance of colorblindness in Akoto family. Colorblindness is a recessive and X-linked trait (x®). The allele for normal vision is dominant and is represented by X°. 1 2 3 5 5 6 IV 2 1. What are the genotypes of the founding parents (I-1, l-2)? 2. What is the percentage of the affected offspring (II)? 3. What is the phenotype of Il-2? 4. Is the inheritance autosomal or sex-linked? 2.

Explain your answer. Below is a pedigree showing the inheritance of colorblindness in Akoto family. Colorblindness is a recessive and X-linked trait (x®). The allele for normal vision is dominant and is represented by X°. 1 2 3 5 5 6 IV 2 1. What are the genotypes of the founding parents (I-1, l-2)? 2. What is the percentage of the affected offspring (II)? 3. What is the phenotype of Il-2? 4. Is the inheritance autosomal or sex-linked? 2.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 17QP: Analysis of X-Linked Dominant and Recessive Traits A young boy is color-blind. His one brother and...

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Analysis of X-Linked Dominant and Recessive Traits A young boy is color-blind. His one brother and five sisters are not. The boy has three maternal uncles and four maternal aunts. None of his uncles children or grandchildren is color-blind. One of the maternal aunts married a color-blind man, and half of her children, both male and female, are color-blind. The other aunts married men who have normal color vision. All their daughters have normal vision, but half of their sons are color-blind. a. Which of the boys four grandparents transmitted the gene for color blindness? b. Are any of the boys aunts or uncles color-blind? c. Is either of the boys parents color-blind?
A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What if the couple wanted prenatal testing so that a normal fetus could be aborted?