Fentanyl is a synthetic opioid that is used for pain management. Fentanyl has a piperidyl ring - a 6-membered ring containing a nitrogen – in its molecular structure. Which conformation of the ring is likely to be lowest in energy (and thus most likely to bind to the opioid receptors)? Explain. A C D
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- Which of the following bonds absorbs higher energy? O--H or C--H? Why?Organic ChemistryFor each pair of compounds, indicate whether the first structure is lower, higher, or about the same in energy as the second structure. Be sure to explain. C angle (c) CH3 OH is OH in energy than/as H3C because: Po (d) CN CN NC- CN CO₂Et is in energy than/as CO₂Et CO₂Et EtO₂C because:Which conformer(s) below represents highest energy staggered conformation of 2- methylbutane? H H CH3 CH3 I 1 || H ||| CH3 I and II CH3 Ø H₂C H II H CH3 H H CH3 H III CH3 CH3
- As mentioned in Problem 3-53, the statin drugs, such as simvastatin (Zocor), pravastatin (Pravachol), and atorvastatin (Lipitor) are the most widely prescribed drugs in the world. (a) Are the two indicated bonds on simvastatin cis or trans? (b) What are the cis/trans relationships among the three indicated bonds on pravastatin? (c) Why cant the three indicated bonds on atorvastatin be identified as cis or trans?Consider the molecule 1-bromo-2-methylbutane. C3 and C4 should be drawn as Et as in theexample. This group is called an ethyl group and can be considered a sphere about twice the sizeof a methyl group. Draw the following Newman projections sighting down the C1C2 bond... a. The lowest potential energy conformation. b. The highest potential energy staggered conformation.5) What is the relationship between each of the following pairs of molecules? Are the underlined answers correct? Explain. Br and Br (Identical Not Isomers Enantiomers Diastereomers I dentical the pos.tion of methul and Bromine becaure are at I and 3, Axial position. (b) Not Isomers Identical Enantiomers Diastereomers Br Br Br and Br (c) CHO CHO H OH HO--H COOH Not Isomers HO-H HO--H ČOOH Enantiomers Diastereomers Identical and (d) Br Enantiomers Diastereomers Not Isomers and Identical Br
- Draw the skeletal structure of a neutral acyclic molecule with one tetrahedral stereocenter. You may use only 8 carbon atoms and 1 halogen atom, plus as many hydrogen atoms as you like. Click and drag to start drawing a structure. S Shm CB) م -------------------- (CH₂)18 CH₂ (CH₂)18 CH₂ * 3 NaOH ??-2 ??-??Compound CI a b a OH C b OH Ortho, meta or para ΝΑ Total # aromatic Hs 5 # of Types of aromatic Hs 3 (see letters) Total # aliphatic (regular alkyl) Hs 3 # of Types of aliphatic Hs 1
- PPh3, DIAD CH20H (A) THF mitsunobu H2N sreaction NH2 excess AGOH () (Ci3H20 INS) me I N-me me5. different compounds b) that are not isolielss bicucional isomers! a) How many stereocenters does this compound have? How many stereoisomers are possible for this compound? Write most under the memb NH₂ most stable. each trio which is least stable. NH₂Compounds 1 and 2 were prepared, and the difference in their heats of combustion was found to be 17.2 kJ/mol (J. Am. Chem. Soc. 1961, 83, 606-614): H H 1 Shown below are the lowest-energy conformations of compounds 1 and 2. Identify which drawing matches which compound, and identify which compound has the larger heat of combustion. H H H H |||I 2 H 4 H H The first drawing is compound 1, and compound 1 has a larger heat of combustion because it is the less stable compound. O The first drawing is compound 2, and compound 2 has a larger heat of combustion because it is the less stable compound. The first drawing is compound 2, and compound 2 has a larger heat of combustion because it is the more stable compound. The first drawing is compound 1, and compound 1 has a larger heat of combustion because it is the more stable compound.