Finally, discuss the consequences of 9.2 uM for actin polymerization in a cell, considering critical concentrations values of 0.1 uM for barbed (plus) end addition and 0.6 uM for pointed (minus) end addition of actin. Recall that at G-actin concentrations above the critical concentration, actin filaments elongate. When the G-actin concentration is greater than the Cc for the barbed end (C (T)) but less than the Cc for the pointed end (Cc (D)), the filament maintains a steady state length due to treadmilling, where the rate of ATP actin addition at the barbed end equals the rate of ADP-actin at the pointed end.

Finally, discuss the consequences of 9.2 uM for actin polymerization in a cell, considering critical concentrations values of 0.1 uM for barbed (plus) end addition and 0.6 uM for pointed (minus) end addition of actin. Recall that at G-actin concentrations above the critical concentration, actin filaments elongate. When the G-actin concentration is greater than the Cc for the barbed end (C (T)) but less than the Cc for the pointed end (Cc (D)), the filament maintains a steady state length due to treadmilling, where the rate of ATP actin addition at the barbed end equals the rate of ADP-actin at the pointed end.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter32: The Reception And Transmission Of Extracellular Information

Section: Chapter Questions

Problem 11P

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