Fishes living in areas where there is a runoff of estrogens experience a decrease in fertility; however, a researcher found that this trait was not multigenerational. This scenario is a result of Environment Genetics None of the above Epigenetics
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- In Figure 6-21, propose a specific genetic explanationfor individual Q (give a possible genotype, defining theallelesFor Mendelian inheritance, the nuclear genotype (i.e., the allelesfound on chromosomes in the cell nucleus) directly influences anoffspring’s traits. In contrast, for non-Mendelian inheritance patterns, the offspring’s phenotype cannot be reliably predicted solelyfrom its genotype. For the following traits, what do you need toknow to predict the phenotypic outcome?A. Dwarfism due to a mutant Igf2 alleleB. Snail coiling directionC. Leber hereditary optic neuropathyAmong mammals, measurements of the rate of generation of autosomal recessive mutations have been madealmost exclusively in mice, while many measurementsof the rate of generation of dominant mutations havebeen made both in mice and in humans. What do youthink is the reason for this difference?
- Explain, at the molecular level, why human genetic diseases oftenfollow a simple Mendelian pattern of inheritance, whereas mostnormal traits, such as the shape of your nose or the size of yourhead, are governed by multiple gene interactions.Imagine that you caught a female albino mouse inyour kitchen and decided to keep it for a pet. A fewmonths later, while vacationing in Guam, you caughta male albino mouse and decided to take it home forsome interesting genetic experiments. You wonderwhether the two mice are both albino due to mutations in the same gene. What could you do to find outthe answer to this question? Assume that both mutations are recessive.Two different genes control the expression of kernelcolour in Mexican black corn: a black pigment gene (B)and a dotted pigment gene (D). Gene B influences theexpression of gene D. The dotted phenotype appearsonly when gene B is in the homozygous recessivestate. A colourless variation occurs when both genesare homozygous recessive.After pure-breeding black-pigmented plants werecrossed with colourless plants, all offspring wereblack-pigmented. Plants of the F1 generation are suspected of being heterozygous for both genes. A test crossof colourless plants with the heterozygote plants should produce a genotypic ratio in theoffspring ofa. 1:0b. 3:1c. 2:1:1d. 1:1:1:1
- When mice carrying the Avy allele exhibit a darker coat, thisphenotype is thought to be caused by dietary factors thatresult ina. a greater level of DNA methylation and a decrease in theexpression of the Agouti gene.b. a lower level of DNA methylation and a decrease in theexpressionof the Agouti gene.c. a greater level of DNA methylation and the overexpressionof the Agouti gene.d. a lower level of DNA methylation and the overexpression ofthe Agouti gene.Figure 19-18a shows a plot of P values (represented bythe dots) along the chromosomes of the dog genome.Each P value is the result of a statistical test of association between a SNP and body size. Other than the clusterof small P values near IGF1, do you see any chromosomalregions with evidence for a significant association between a SNP and body size? Explain.Certain forms of human color blindness are inherited as X-linkedrecessive traits. Hemizygous males are color-blind, but heterozygous females are not. However, heterozygous females sometimeshave partial color blindness.A. Discuss why heterozygous females may have partial color blindness.B. Doctors identified an unusual case in which a heterozygousfemale was color-blind in her right eye but had normal colorvision in her left eye. Explain how this might have occurred.
- Ancient societies used knowledge that traits are heritable in domesticating animals and developing agricultural crops. What might account for the failure to recognize that the same processes operate in humans?Effect of Paternal Grandmothers Food Supply on Infant Mortality Researchers are investigating long- reaching epigenetic effects of starvation, in part because historical data on periods of famine are widely available. Before the industrial revolution, a failed harvest in one autumn typically led to severe food shortages the following winter. A retrospective study has correlated female infant mortality at certain ages with the abundance of food during the paternal grandmothers childhood. FIGURE 10.12 shows some of the results of this study. FIGURE 10.12 Graph showing the relative risk of early death of a female child, correlated with the age at which her paternal grandmother experienced a winter with a food supply that was scarce (blue) or abundant (red) during childhood. The dotted line represents no difference in risk of morality. A value above the line means an increases risk; one below the line indicates a reduced risk. 3. There was no correlation between early death of a male child and eating habits of his paternal grandmother, hut there was a strong correlation with the eating habits of his paternal grandfather. What does this tell you about the probable location of epigenetic changes that gave rise to these data?Effect of Paternal Grandmothers Food Supply on Infant Mortality Researchers are investigating long- reaching epigenetic effects of starvation, in part because historical data on periods of famine are widely available. Before the industrial revolution, a failed harvest in one autumn typically led to severe food shortages the following winter. A retrospective study has correlated female infant mortality at certain ages with the abundance of food during the paternal grandmothers childhood. FIGURE 10.12 shows some of the results of this study. FIGURE 10.12 Graph showing the relative risk of early death of a female child, correlated with the age at which her paternal grandmother experienced a winter with a food supply that was scarce (blue) or abundant (red) during childhood. The dotted line represents no difference in risk of morality. A value above the line means an increases risk; one below the line indicates a reduced risk. 1. Compare the mortality of girls whose paternal grandmothers ate well at age 2 with that of those who experienced famine at the same age. Which girl was more likely to die early? How much more likely was she to die?
