Following the activity of acetylcholinesterase, choline is A. Transported back into the neuron using a sodium gradient O B. Transported into nearby glia where it is used to synthesize additional acetylcholinesterase enzym OC. Taken into the postsynaptic cell and stored for further release D. Released into the extracellular fluid where it diffuses away from the synaptic cleft and is degradec
Please ASAP. Thank you.
The neurotransmitter acetylcholine (ACh) is released from pre-synaptic neuron into the synaptic cleft. ACh then binds to the receptors on the post-synaptic nerve. The resulting conformational change of the receptor leads to the opening of voltage-gated calcium channels. The post-synaptic neuron gets excited, and the signal is further transmitted through the neuron. The enzyme Acetylcholinesterase (AChE) hydrolyze and remove ACh from the receptor.
AChE is a cholinergic enzyme, mainly found at post-synaptic neuron. It hydrolyses Ach into choline and acetic acid. This hydrolysis prevents continuous activation of receptors and termination of the signal. Acetate diffuses into the medium in the synaptic cleft, and choline is transported by Na+/choline symporter into the pre-synaptic neuron.
Thus, option (1) is correct
Step 3
Option (2) is incorrect because choline is used to synthesis acetylcholine neurotransmitters in pre-synaptic neurons.
Option (3) is incorrect because the high-affinity choline uptake system stores choline in the pre-synaptic neuron.
Option (4) is incorrect because choline is transported back into the neuron via synaptic cleft and not degraded in the extracellular medium.
Step by step
Solved in 3 steps
