For each of the following statements, indicate whether it is true or false. [Select] [Select] The LDL particles are internalized through the endocytic pathway. A mutation that impairs the association of the LDL receptor with adaptin would cause depletion of LDL in the blood. [Select] In the endosome, the LDL particle dissociates from the LDL receptor because the pH in the endosome is higher than that in the transport vesicle. [Select] A mutation that impairs the recruitment of the LDL receptor into clathrin-coated vesicles would cause a decrease in cellular cholesterol level.

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter16: The Digestive System
Section: Chapter Questions
Problem 4TAHL
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Protein A is a transmembrane protein in the plasma membrane. Its N-terminus is on the cytoplasm
side and its C-terminus is on the extracellular side. During its transport through the endomembrane
system, what should its orientation be in various compartments that it travels through? Determine
whether the N or C-terminus of protein A should be in the lumens of ER, Golgi, and the transport
vesicles.
[Select]
[Select]
[Select]
ER lumen
Golgi lumen
✓ Transport vesicles lumen
Transcribed Image Text:Protein A is a transmembrane protein in the plasma membrane. Its N-terminus is on the cytoplasm side and its C-terminus is on the extracellular side. During its transport through the endomembrane system, what should its orientation be in various compartments that it travels through? Determine whether the N or C-terminus of protein A should be in the lumens of ER, Golgi, and the transport vesicles. [Select] [Select] [Select] ER lumen Golgi lumen ✓ Transport vesicles lumen
For each of the following statements, indicate whether it is true or false.
[Select]
[Select]
The LDL particles are internalized through the endocytic pathway.
A mutation that impairs the association of the LDL receptor with
adaptin would cause depletion of LDL in the blood.
[Select]
In the endosome, the LDL particle dissociates from the LDL
receptor because the pH in the endosome is higher than that in the transport vesicle.
[Select]
A mutation that impairs the recruitment of the LDL receptor into
clathrin-coated vesicles would cause a decrease in cellular cholesterol level.
Transcribed Image Text:For each of the following statements, indicate whether it is true or false. [Select] [Select] The LDL particles are internalized through the endocytic pathway. A mutation that impairs the association of the LDL receptor with adaptin would cause depletion of LDL in the blood. [Select] In the endosome, the LDL particle dissociates from the LDL receptor because the pH in the endosome is higher than that in the transport vesicle. [Select] A mutation that impairs the recruitment of the LDL receptor into clathrin-coated vesicles would cause a decrease in cellular cholesterol level.
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