Answered: For immunoglobulin heavy and light…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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For immunoglobulin heavy and light chain genes, and for T-cell receptor b chain genes, there are a large number of V gene segments, and relatively few J and/or D segments that rearrange to form the final coding sequence for each gene. The TCR a locus is different in this regard, and this difference is thought to reflect the fact that nearly all a:b T-cell receptors recognize a peptide bound to an MHC molecule. This unique feature of the T-cell receptor a locus is:

The presence of only five different Va gene segments
The presence of two different Ca coding sequences
The presence of over sixty different Ja gene segments
The absence of D gene segments
The large sequence distance separating the Va gene segments from the Ja gene segments

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