Galactose 1-phosphate: UDP-glucose uridyltransferase (GALT) is an enzyme important for the catabolism of galactose.  Patients with GALT deficiency present within days of birth with feeding difficulty, fatigue, jaundice and liver problems, and failure to thrive.  In addition, a buildup of galactose and its metabolites are present in the bloodstream.  GALT catalyzes the following reaction in galactose catabolism.  NOTE that GALT is reversible!! Classify this enzyme and explain why you classified it in this way.

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter10: From Proteins To Phenotypes
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Galactose 1-phosphate: UDP-glucose uridyltransferase (GALT) is an enzyme important for the catabolism of galactose.  Patients with GALT deficiency present within days of birth with feeding difficulty, fatigue, jaundice and liver problems, and failure to thrive.  In addition, a buildup of galactose and its metabolites are present in the bloodstream.  GALT catalyzes the following reaction in galactose catabolism.  NOTE that GALT is reversible!!

Classify this enzyme and explain why you classified it in this way.

 

 

CH2OH
Но
H
OH H
o-O Galactose 1-phosphate
H
ÓH
UDP-
UDP-glucose: galactose 1-
phosphate uridylytransferase
glucose
Glucose 1-phosphate
CH2OH
UDP-galactose
Но
H
H
он н
H
ó-UDP
он
Transcribed Image Text:CH2OH Но H OH H o-O Galactose 1-phosphate H ÓH UDP- UDP-glucose: galactose 1- phosphate uridylytransferase glucose Glucose 1-phosphate CH2OH UDP-galactose Но H H он н H ó-UDP он
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