HC CH reaction with HC CH lysosome .CH CH HC CH3 HC CH3 H2 HC C CH HC CH CH3 CH3 OH OH inside the cell, propranolol sometimes encounters lysosomes, which alter its NH group as shown above (right). reacting with the lysosomes, propranolol becomes trapped inside the cell and can cause psoriasis or other inflammatory side effects. Use IMFS to explain why the altered propranolol gets trapped. T
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- . Lysozyme is placed in a dialysis tube. The protein has a charge of +18 at pH 7.0. If the protein is dialyzed against 0.1L of 0.1M NaCl, predict the sign of the membrane potential using the Donnan Potential.Of the following cell membrane lipids, which one prefers to reside in the INNER leaflet (or inner half) of the membrane bilayer, AND is zwitterionic at physiological pH (7.4)? PS (phosphatidylserine) is inner-leaflet & zwitterionic PC (phosphatidylcholine) is inner-leaflet & zwitterionic 3 of these 4 responses are correct SM (sphingomyelin) is inner-leaflet & zwitterionic PE (phosphatidylethanolamine) is inner-leaflet & zwitterionicYou are studying the binding of proteins to thecytoplasmic face of cultured neuroblastoma cells andhave found a method that gives a good yield of inside-outvesicles from the plasma membrane. Unfortunately, yourpreparations are contaminated with variable amounts ofright-side-out vesicles. Nothing you have tried avoids thisproblem. A friend suggests that you pass your vesicles overan affinity column made of lectin coupled to solid beads.What is the point of your friend’s suggestion?
- Comparing cells synthesizing secretory proteins and cells secreting steroid hormones, the cells synthesizing the steroid hormones have: A) more rough ER. B) more smooth ER C) equal amounts of smooth and rough ER D) equal amounts of smooth and rough ER, but more lysosomes. E) equal amounts of smooth and rough ER, but fewer lysosomes.If the RGD tripeptide sequence in fibronevtin wete absent. Which is true? integrims would not bind to fibronectin cadherins on adjacent cells would not be able to interact in a homotypic fashion. fibronectin could not form crosslink with other extracellular matrix proteins. glycosaminoglycans would not be able to assemble onto proteoglycans.Select the correct statement regarding the actin cytoskeleton. They are involved in the formation of the axoneme. Actin microfilaments are the most stable cytoskeleton network. Can undergo catastrophe due to GTP hydrolysis-mediated conformational changes. Synthesis and degradation of actin microfilaments is directional, with g-actin subunits added only to the + end of the microfilament while depolymerization occurs at the - end. From the list below, select the correct statements regarding the genetic code. Codons code for 30 distinct amino acids. The basis of the genetic code are codons. The genetic code has a possible 64 different codons. The genetic code has built-in degeneracy. Codons are formed by 5 consecutive nucleotides.
- Flippases help maintain membrane asymmetry. True FalseThe amino acid sequence Leu-His-Arg-Leu-Asp-Ala-Gln-SerLys-Leu-Ser-Ser is a signal sequence that directs proteinstowards the endoplasmic reticulum, say if it is true or false if it is false justify it.Heparan sulfate proteoglycans appertain to which of the following processes?*a. transport by argosomesb. transport by cytonemesc. restricted diffusiond. simple diffusion The model for planar transcytosis is characterized by which of the following?* a. Morphogen-receiving cells employ long actin-based filopodia. b. Morphogens interact with cell surface receptors and coreceptors. c. Lipid-modified morphogens are transported in lipoprotein vesicles. d. Morphogens are transported by repeated rounds of endocytosis and re-secretion. Metamerism is NOT observed in which of the following structures?* a. acron b. rhombomeres c. somites d. vertebral column The anterior structure of the Drosophila is promoted by which of the following events?* a. nanos proteins block the transcription of the caudal gene. b. caudal proteins promote the transcription of the bicoid gene. c. bicoid proteins promote transcription of the…
- Phagocytosis of a bacterial cell by a macrophage, involves extensive remodeling of the actin microfilaments in the cell cortex to produce extensions of the plasma membrane and formation the phagocytic cup. Based on your knowledge of microfilament assembly/disassembly and related cell membrane deformation, explain the underlying processes that would be involved in formation of the phagocytic cup.REEP family proteins act as wedges to promote bending of the membrane true or falseMany of the cell’s hydrolytic enzymes are located in the lysosome, where the pH is ∼5. What would you expect to be the optimum pH for these enzymes, and why would this protect the rest of the cell from the destructive power of these enzymes upon the accidental rupture of a lysosome?