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Hormone Inactive adenylyl cyclase GTP Target cell GDP Blood vessel a Subunit of G, protein 3 dissociates from By and activates adenylyi cyclase. Active adenylyl cyclase Direct contact ATP Gap junction GTP CAMP + PP When hormone is no longer present, the receptor reverts to resting state. GTP on the a subunit is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell -Target cells Inactive adenylyl cyclase GOP

Hormone Inactive adenylyl cyclase GTP Target cell GDP Blood vessel a Subunit of G, protein 3 dissociates from By and activates adenylyi cyclase. Active adenylyl cyclase Direct contact ATP Gap junction GTP CAMP + PP When hormone is no longer present, the receptor reverts to resting state. GTP on the a subunit is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell -Target cells Inactive adenylyl cyclase GOP

Anatomy & Physiology
Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter12: The Nervous System And Nervous Tissue
Section: Chapter Questions
Problem 8ILQ: Watch this video (http://openstaxcollege.org/l/neurotrans) to learn about the release of a...
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4. Explain the mechanism of action of the adenyl cyclic system using
 aschematic diagram.

1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
Transcribed Image Text:1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
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