How is Rh incompatibility involved in hemolytic disease of the newborn? Is the mother Rh+ or Rh-? Is the fetus Rh+ or Rh-? Why is a second child that is Rh+ more susceptible to attack from the mother’s immune system.

How is Rh incompatibility involved in hemolytic disease of the newborn? Is the mother Rh+ or Rh-? Is the fetus Rh+ or Rh-? Why is a second child that is Rh+ more susceptible to attack from the mother’s immune system.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 20QP

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Expert Solution

Step 1 Introduction

The study of antigen and antibody interactions is known as serology. There are several antigens present on the surface of the red blood cells. These antigens give rise to different blood groups. There are many blood grouping systems like ABO, Rh, Duffy, Lewis, and MNS systems.

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Under what conditions might a person with Rh- blood develop Rh antibodies? Why can Rh+ blood be given only once to a non-sensitized person who is Rh-?
How does a baby inherit Rh+ blood from an Rh− mother?
Why is Rh incompatibility rare today?
Why is it that Rh incompatibility can be a serious problem when anRh-negative mother is carrying an Rh-positive fetus, but ABOincompatibility between mother and fetus is usually no problem?That is, a type A mother can usually safely carry a type B fetus.(Hint: The antibodies produced by an Rh-negative mother againstthe Rh antigen are usually IgG, whereas the antibodies producedagainst the A or B antigens are IgM.) Because the Rh antigenobviously serves no vital function (most humans lack it), why do youthink it hasn’t been completely eliminated during human evolution?
How are the antibodiesagainst the Rh factor formed?
A woman who is Rh- mates with a man who is Rh+. Since the Rh+ is dominant, what would the fetus's Rh factor type be?A person who is Rh- can donate blood to other people who are either Rh+ or Rh-. However, an Rh+ person can only give blood to who? Please explain.
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Below are the ABO and Rh blood types of some couples. If during birth some blood is exchaged between the mother and the first newborn, the second newborn of which couple has the LEAST chance for suffering from hemolytic disease of the newborn due to Rh incompatibility? Consider both Rh and ABO incompatibilities. A. Wife B -, husband O + B. Wife AB -, husband AB + C. Wife AB -, husband O+ D. Wife O -, husband B + E. Wife A -, husband O+
It was stated that Rh antigens are so sparsely scattered in the red cell surface that IgG molecules bound to the Rh antigens are too far apart to fix C1q.Therefore, complement-mediated hemolysis cannot be invoked to explain hemolytic disease of the newborn. By what mechanism are the red cells destroyed?
LIST OF THE BLOOD TYPES FROM WHICH THE FOLLOWING PEOPLE COULD RECEIVE, ASSUMING THE RECIPIENTS HAVE BEEN EXPOSED TO Rh antigens: Recipient:type O+ Recipient: Type B+ Recipient: type A- Recipient: type AB-