How many diff erent heavy chain variable regions can theoretically be generated by somatic recombination in humans (ignore junctional flexibility)? If each of these heavy chains could combine with any of the ~2000 κ light chains, how many different immunoglobulins could be produced?
How many diff erent heavy chain variable regions can theoretically be generated by somatic recombination in humans (ignore junctional flexibility)? If each of these heavy chains could combine with any of the ~2000 κ light chains, how many different immunoglobulins could be produced?
Somatic recombination is a recombination process where immune cells (B, T) of the adaptive immune system cleaves small regions or segments of DNA, and the remaining pieces of DNA are joined together in an error-prone way to achieve recombination.
Somatic recombination occurs during the assembly of the B and T-cell receptor genes (V D J recombination). Also during the gene rearrangement of immunoglobulins. Somatic recombination plays role in cancer formation.
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