i. Calculate the Log-P values of the following drugs. ii. Are these compounds hydrophilic or lipophilic? H. (CH3)3CN. COOH N- CH3 HS HO Captopril HO он Nadolol

Q: .CO2H + NaHCO3 (aq) A. Circle the molecule that reacts with sodium bicarbonate. B. Draw the organic…

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Q: write the mecharism of each reaction a) Base R-X HOẠC. NaBHy HOAC C

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Q: A key transformation in the original synthesis of cocaine was the synthesis of 1,3cyloheptadiene…

A: The synthesis of 1,3-cycloheptadiene from cycloheptanol can be shown through the reaction given…

Q: 2. Phenobarbital `NH C2H5 Synthesis: OEt EtO NaOEt OEt - co OEt OEt Eto OEt H3C Br NaOEt H2N `NH2…

A: The steps involved in the following synthesis are the abstraction of proton to form nucleophile,…

Q: (Rank each of the molecules from least to most nucleophilic with 1 being the least four being the…

A: In chemistry, a nucleophile is a chemical species that forms bonds with electrophiles by donating an…

Q: Which of the following compounds is the most nucleophilic? A) CH;SH В) CH,ОН С) Н,О D) CH;CO,H E)…

A: Out of them the most nucleophilic is

Q: 2. Phenobarbital NH C2H5 Synthesis: LOEt EtO - Co OEt OEt NaOEt OEt OEt Eto H3C `Br NaOEt H2N NH2…

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Q: 4. Provide the reagents (at the reaction arrows, use 1).... 2).... if more than one step is needed)…

A: 1) First reaction is haloform reaction. Addition of dihalogen to methyl ketone in presence of base…

Q: RCHO + HCN > RCH(OH)CN Construct the equation for the reaction reactions of following a) Butanal…

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Q: 10. What the product of the following reaction. 1./ MgBr (*xcess) 2. H20

A: When ester react with excess grignard reagent then tertiary alcohol is formed.  For more than one…

Q: 3. What is the most likely product for the following reaction? 1. Br2, NaOH / H20 2. HCI CBr3 HO,…

A: This is haloform reaction. Product of this reaction is, carboxylic acid.

Q: 2a. Which of the following compounds is the strongest electrophile? NH2 HO B D

A: 1- ( C ) compound amide is poorest electrophile than ester ( D ) and carboxylic acid ( A ) because…

Q: Select all the possible reducing sugarls from the list below. CH2OH c=0 CHO HHOH HO-H HHOH CH2OH Fо…

A: Reducing sugars are those carbohydrates which oxidized itself by using oxidizing agent and these…

Q: 7. Which of (a)-(d) is least likely as an intermediate or product in the following reaction? cat. H*…

A: Reaction of aldehydes and ketones with hydroxylamine (HONH2) gives oximes.

Q: H;C Which reaction is most likely to form this compound? CH,CH,CH, OH NaOH A Br Na ОН В H3C

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Q: 8. Write the main product for the following elimination reactions: o bb Br H. Et NaOCH3 MEOH/heat Pr…

A: “Since you have posted a question with multiple sub-parts, we will solve first three subparts for…

Q: How many nucleophilic centers are present in this molecule? oho „NH2

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Q: Which of the attached compound is the most nucleophilic ?

A: A nucleophile is the one, which can donate lone pair of electrons.

Q: Propose a mechanism for this reaction. Account for both its regioselectivity and stereoselectivity.

A: In the cholesterol molecule, The alkene acts as nucleophile and the attacks the HOCl. The…

Q: Which reagent will accomplish the following reaction? Select one: O a. 1. BH3; 2. NaOH, H202 O b.…

A: The above conversation takes place by O2/ Ag2O, In this reaction, epoxide will form (a) 1)BH3, 2)…

Q: 2. Complete the following reactions. If no reaction occurs, write "No reaction" a) HO-CH₂- b) CH3 -…

A: Concept a. Normal oxidation of -CH2OH to -COOH b. Alpha hydroxy acid under heating condition…

Q: What is a major product of the reaction shown in the box? Pd-cat 1. LIAIH4 ? H3CO- -CHO Base 2. H20…

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Q: Which of the compounds below has a pka that most closely matches the pka of butanethiol? O…

A: pKa  It is the value with which the acidic strength is determined. pKa=-log(Ka) Lower the value of…

Q: 0.. Gio

A: Proper reason explained below.

Q: Which of the following molecules cannot act as a nucleophile? (B) NH (C) BII, (D) PH, 10. Given that…

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Q: For the reaction between 1-bromobutane and NaOH to form 1-butanol, what is the nucleophile? O OH O…

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Q: 1/ Hydrolysis of CH;CH,NO, with 85% H,SO, gives?

A: As per company norms we cannot answer more than one question per session .So, I have answered…

Q: 7. Whch one of the following reagents will not transform an aldehyde to a carboxylic acid ? с)…

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Q: draw the arrow-pushing mechanisnm of the following reaction: OH H,SO4

A: Given: Dehydration reaction of 1cyclopentyl alchol to give cyclohexene To find: The mechanism of the…

Q: 5. Complete the following reactions by writing the correct product Ph H- OTs NaOCH3 H- Ph Methanol…

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Q: Choose the one has the highest priority, and the one has the lowest. (Please show why)

A: Order of priority of functional groups are : -COOH > –SO3H >-COOR (R=alkyl group) > COCl…

Q: ОН HO HO. H2SO4 + Ме "Ме ОН Ме "Ме

A: The given reaction between acetone and 1,2,3-propanetriol in the presence of H2SO4 leads the…

Q: Q52. How may concentrated acid or concentrated base be safely mixed with water? Q53. What is the…

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Q: What is the major product of the following reaction sequence? 1. H2, Pd'CaCO3, quinoline 2a BH3:THF…

A: H2, Pd / CaCo3 , quinoline is also known as Lindlar catalyst which is an heterogeneous catalyst and…

Q: 1NODET roomteme 2. CH3 CH2B (1 equi)" Enolate Anion + Katone Aldehyde OH 1. NAOH 2.neut wakup…

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Q: CH;CH, -NH, + CH, C-OH A product of the reaction above would be a(n) alkene salt O secondary amine O…

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Q: In the following reaction, which chemical species is acting like a nucleophile? 5 H,CO N- CH;O* a)…

A: The chemical species can be divided as electrophile and nucleophile on the basis of the electron…

Q: 1. 9-BBN 2. Н2О2/NaOH 9-BBN %3D -BH 3. H*/H2O

A: Organoborane reaction mechanism

Q: c) Which of the following phenolic compounds has the lowest pKa value? Explain. co.o HO, но ÓH A В

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Q: Choose the most appropriate reagent(s) for the conversion of the ketone to the primary amine…

A: H2/ Pd is used to reduce the alkenes present in the reactants. The reaction of NaNH2 and NH3 is a…

Q: In the following reactions substituent X was varied between electron donating and electron…

A: The effect of the substituents on the rate (n) of a chemical reaction is expressed by the Hammet…

Q: Which molecule will most easily undergo decarboxylation when heated? d. 51. b. HO. HO HO HO. HO

A: In decarboxylation reaction carboxylic acid decomposes to give carbon dioxide. Beta keto acid gives…

Q: 8. Draw the structures of the conjugate acid and base for the following reaction. Provide the…

A: pKa is inversely proportional to acidity.  So lesser pka, stringer the acid is.

Q: 1. For each of the following molecules, put a box around the nucleophilic atom(8). MgBr SH H.

A: A nucleophile is a species which is highly electron rich in nature while an electrophile is defined…

Q: Which of the following compounds is the most nucleophilic? CH;SH • CH;OH HO CH,CO2H BF3

A: Nucleophiles (Means nucleus seeking species)- The species which are electron rich called as…

Q: The major product of the following reaction is H,Cro, acetone Он H20

A: Major product: The product that is produced in the greatest amount in a chemical reaction.Minor…

Q: Methamphetamine can exist in two possible forms, shown below: Mr. Mema is trying to convert…

A: A contains nitrogen atom with l.p. on it. Hence, it is basic in nature.  B is a salt.  We know that…

Q: (8 pts) Which of the following compounds will decarboxylate (lose carbon dioxide) in the presence of…

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Q: [ 15] What compounds result from following ? H30* ? ( a) ortho-methyl benzoic acid + 1-butanol (b)…

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