I. The alkylated product is poor with primary alkyl halides. II. Primary alkyl halides are best suited for alkylation. III. In the presence of tertiary alkyl halides, the acetylide anion acts as base to give an elimination product.

I. The alkylated product is poor with primary alkyl halides. II. Primary alkyl halides are best suited for alkylation. III. In the presence of tertiary alkyl halides, the acetylide anion acts as base to give an elimination product.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter26: Aldol And Claisen Reactions

Section: Chapter Questions

Problem 37E

See similar textbooks

Related questions

Q: Which statement best describes what is happening in step 6? (Remember, this is copied from the full…

A: In the given step left side one is imine. Imine is converted to examine through tautomerisation

Q: Use the appropriate reagent used in the reaction. (d),(e) please!!

A: Here we have to mention the appropriate reagent for reaction d and reaction e-

Q: Why we need step 3 before step 4? a. Because the nitro group increases the electrophilicity at the…

Q: A student wanted to know whether the greater proximity of the ucleophile to the C-2 carbon in the…

A: The reaction of HCl with 2-methyl-1,3-cyclohexadiene will form 1,2-addition product and 1,4-addition…

Q: OEt Drag the appropriate labels to their respective targets. Rese H H H. NaOEt NAOH Ph Ph OEt EtO…

Q: Which is the better nucleophile in a protic solvent, chloride ion or bromide ion? Try to explain…

A: The periodic table consists of arranged elements according to their periodicity. The halogens belong…

Q: A different way of synthesising the product 4,4- diphenylbut-3-en-2-one is via an aldol…

A: aldol condensation is a condensation reaction in which an enolate ion reacts with a carbonyl…

Q: How does the strength of the nucleophile affect an SN1 or SN2 mechanism?

A: Given reaction types, SN1 reaction mechanism SN2 reaction mechanism

Q: 1. Write the reaction that you will do this week for the Williamson ether synthesis. Label the…

A: Organic synthesis.

Q: OH HO Br HO

A: The question is based on the concept of chemical conversions. we have been given reactant and…

Q: Williamson Ether Synthesis One of the side reactions in this reaction is the C-alkylation. How does…

A: Here we have to say how C-alkylation product is formed in williamson's synthesis and poduct look…

Q: synthesis. the letters of the reagents in the order that they are used; example: fa. Reagents…

A: Given : We have to write the reagent and prepare the given product from benzene.

Q: [4] In STEPS 9-10, a hydroxide ion causes the anhydride to break down and cleave into two products.…

Q: 6 Show how to synthetize the following target: (a)

A: Organic reaction mechanisms.

Q: In the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate…

A: Friedel crafts alkylation reaction in which the Hydrogen of the benzene ring is replaced with the…

Q: /hich reaction sequence will most successfully generate the product shown belov (1) HNO3/H2SO4 (A)…

A: the solution is given below -

Q: 1) Which one of the following compounds cannot react with another equivalent of itself in an aldol…

A: As per our guidelines we are supposed to solve only the first question. Please post other questions…

Q: Why does increasing alkyl substitution increase the rate of an E2 reaction?

A: The increase in E2 reaction rate with increasing alkyl substitution can be rationalized in terms of…

Q: In the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate…

A: It is an example of electrophilic aromatic substitution reaction

Q: i) (CH3)3N: (CH3)2ö: W ii)

Q: 4) Vocabulary: words are given circle the correct one. a. A Robinson Annulation can occur with…

Q: BrMg. 1. 1 CI CI starting point 2. H3O* compound A

Q: Explain why alkylation of an α-carbon works best if the alkyl halide used in the reaction is a…

A: The alkylation reaction of an α-carbon depends on the R-X (alkyl halide) used in the reaction. The…

Q: Choose the best substrate for a substitution reaction. O Alkyl iodide O Alkyl bromide O Alkyl…

Q: Question attached

A: E1 reaction is unimolecular reaction, where one substituent is removed from the molecule. In a E1…

Q: In each reaction box, place the best reagent and conditions from the list.

A: Cyclohexanone on reaction with Br2/NaOH gives 2-bromo cyclohexanone. This on treatment with…

Q: Why is the following reaction sequence not an efficient approach to the desired product?

A: terminal alkynes contains acidic hydrogens eg: acetylene (ethyne), 1-propyne etc this acidic H…

Q: Identify the stronger nucleophile in each pair of anions.a. Br- or Cl- in a polar protic solventb.…

A: a.Polar protic solvents contain hydrogen atoms bonded to electronegative atoms namely O or N.The…

Q: What is a multi-step synthesis for the following:

A: The final product can be prepared in the following steps:Step 1 : Preparation of alkene from alkyl…

Q: From each pair, select the stronger nucleophile. Q.)Cl- or I- in DMSO

A: The species, that make a covalent bond by donates a pair of electrons is known as nucleophile.…

Q: write or draw the synthetic step to get to the following compounds. (Grignard reaction)

A: Since, you have asked multiple question, we will solve the first question for you. If you want any…

Q: All are true or false a) The initially formed b-hydroxy carbonyl compound loses water in a Aldol…

A: a) The initially formed b-hydroxy carbonyl compound loses water in a Aldol condensation. TRUE- In…

Q: In the E1 reaction, how is the rate affected when the concentration of attacking nucleophile is…

A: Elimination reaction-is type of organic reaction in which two substituents are removed from molecule…

Q: Explain why alkylation of an a-carbon works best if the alkyl halide used in the reaction is a…

A: The alkylation reaction of an α-carbon depends on the R-X (alkyl halide) used in the reaction. The…

Q: aldol condensation reaction followed by dehydration? (Please help me with this reaction)

Q: Write the reagents needed to complete this 1-step synthesis. If multiple, consecutiv reagents are…

A: The given reaction is,

Q: From each pair, select the stronger nucleophile. Q.) CH3SH or CH3S-

A: The species which make a covalent bond by donating a pair of electrons is termed as nucleophile.…

Q: Need help finding the order of Reagents to form the product

Q: 1. Assuming no other changes, what is the effect of doubling both the alkyl halide and the…

A: SN1 reactions are Nucleophilic substitution reactions. These are unimolecular reactions. Thus the…

Q: Draw structures for the carbonyl electrophile and enolate nucleophile that react to give the aldol…

A: The reaction mechanism for the synthesis of given aldol product is,

Q: In the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate…

A: In 1st step to form tert butyl cation Tert butyl alcohol react with acids to give tert butyl…

Q: ?? Remember - can't use simple enolate/enol 7. for SN2 type reaction.

A: For addition to alpha to carbonyl compound, we have to convert that centre to nucleophilic centre.…

Q: 5) Show the complete mechanism for an E2 reaction with 1-bromo-2-tert-butylcyclohexane

A: Answer - 1-bromo-2-tert-butylcyclohexane - A chemical structure of a molecule includes the…

Q: a) What are the correct 1st (involving HCl) and 2nd step (involving NaOH)? Draw out reaction. b)…

A: The given substrate is a tertiary alcohol. The tertiary alcohol reacts with HCl to give tertiary…

Q: For SN1 Explain the order in which 1o (primary) alkyl halides reacted (fastest to slowest) and…

A: The rate of the SN1 reactions depends upon the concentration of alkyl halide only. This kind of…

Q: A student wanted to know whether the greater proximity of the nucleophile to the C-2 carbon in the…

A: The reaction of HCl with 2-methyl-1,3-cyclohexadiene will form 1,2-addition product and 1,4-addition…

Q: What is the reaction mechanism for this final step in an Aldol Condensation

Q: b) In a polar solvent such as water, the SN1 and E1 reactions of a tertiary alkyl halide have the…

A: SN1 is a unimolecular nucleophilic substitution reaction. It is a reaction between an alkyl halide…

Question

Which statement is/are TRUE about acetylide anions?

I. The alkylated product is poor with primary alkyl halides.
II. Primary alkyl halides are best suited for alkylation.
III. In the presence of tertiary alkyl halides, the acetylide anion acts as base to give an
elimination product.

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Protection of Groups in Organic Synthesis

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

This is a umplong reaction. I'm looking for what reagent and intermediates would look like. Thank you
1. Attack the alkyl chloride with the stronger nucleophile. 2. Deprotonated to form the product
[The two reagents in the third step enable an aldol condensation and a Michael addition reaction. You may use a 1-carbon aldehyde.]
show the missing reagents and intermediates in the reaction sequence below
Part 1 - Draw the full mechanism for the cross-aldol reaction between acetone and benzaldehyde Part 2 - Draw the product that would form if we added only one mole each of acetone and benzaldehyde. Part 3 - After forming the initial product, we see the elimination of water to give the final product as a solid that we collect. What drives this product formation?
From each pair, select the stronger nucleophile. Q.)Cl- or I- in DMSO
Can you show step by step of this missing reagent and show the synthetic intermediate?
Write down the product with an appropriate mechanism.
How does the strength of the nucleophile affect an SN1 or SN2 mechanism?
All are true or false a) The initially formed b-hydroxy carbonyl compound loses water in a Aldol condensation. b) Equilibrium favors the starting materials with both aldehydes and ketones for Aldol reactions. c)The Claisen reaction is a type of nucleophilic addition? d) The b-hydroxy carbonyl product of an Aldol reaction is oftentimes not the final isolated product. e)b-Ketoester and an enolate are the two starting materials for a Robinson annulation
What is the right reagent in the reaction below