Identify the functional groups

Introductory Chemistry: An Active Learning Approach
6th Edition
ISBN:9781305079250
Author:Mark S. Cracolice, Ed Peters
Publisher:Mark S. Cracolice, Ed Peters
Chapter22: Biochemistry
Section: Chapter Questions
Problem 23E
icon
Related questions
icon
Concept explainers
Question
Identify the functional groups and predict the solubility of Amoxicillin. Please see tha table for guide and the examples. Examine very well. Provide drawings and explanation please thank u very much. Efforts are highly appreciated.
pi Value
Fragment
C (aliphatic/cyclic)
+0.5
C (alkene-aliphatic/cyclic)
+0.33
(phenyl/benzene ring) C,H;-
+2.0
>/= to +0.5
Halogens (CI, F, Br)
+0.5
water insoluble
O,NO
+0.2
Intramolecular hydrogen bonding (IMHB)
+0.65
< +0.5
+0.5
water soluble
(carboxylic acid) O=C-O
-0.7
(amide) O=C-N
-0.7
O(hydroxyl, phenol, ether)
-1.0
N (amine-aliphatic/cyclic/aromatic)
-1.0
O,N (aliphatic)
-0.85
0,N (aromatic)
-0.28
Benzene 2
TOTAL: 3.95
WATER INSOLUBLE
C-aliphatic=0.5
N cyclic= -1
N
O=CN = -0.7
Benzene 2
HMHB= 0,65
C-aliphatic=0.5
Total: 5.28
Carbon
aliphatice
05
WATER INSOLUBLE
H,CO
Carbon
aliphatic=
0.5
Cyclic
alkene=0.33
H,CO
Carbon
alphatic=
OCH 05
OCN=-0.7
Carbon
OCH3 aliphatic=
6.5
Carbon
cyclic= 0.5
H.C
Benzene=2
Carbon
aliphatice
IMHB= 0.65
0.5
I ZI
Transcribed Image Text:pi Value Fragment C (aliphatic/cyclic) +0.5 C (alkene-aliphatic/cyclic) +0.33 (phenyl/benzene ring) C,H;- +2.0 >/= to +0.5 Halogens (CI, F, Br) +0.5 water insoluble O,NO +0.2 Intramolecular hydrogen bonding (IMHB) +0.65 < +0.5 +0.5 water soluble (carboxylic acid) O=C-O -0.7 (amide) O=C-N -0.7 O(hydroxyl, phenol, ether) -1.0 N (amine-aliphatic/cyclic/aromatic) -1.0 O,N (aliphatic) -0.85 0,N (aromatic) -0.28 Benzene 2 TOTAL: 3.95 WATER INSOLUBLE C-aliphatic=0.5 N cyclic= -1 N O=CN = -0.7 Benzene 2 HMHB= 0,65 C-aliphatic=0.5 Total: 5.28 Carbon aliphatice 05 WATER INSOLUBLE H,CO Carbon aliphatic= 0.5 Cyclic alkene=0.33 H,CO Carbon alphatic= OCH 05 OCN=-0.7 Carbon OCH3 aliphatic= 6.5 Carbon cyclic= 0.5 H.C Benzene=2 Carbon aliphatice IMHB= 0.65 0.5 I ZI
Amoxicillin
NH2 H
N.
.CH3
N-
CH3
НО
co,H
Identify the functional groups present in each
drug and predict the drug solubility based on the
given table. (See attached examples)
Transcribed Image Text:Amoxicillin NH2 H N. .CH3 N- CH3 НО co,H Identify the functional groups present in each drug and predict the drug solubility based on the given table. (See attached examples)
Expert Solution
steps

Step by step

Solved in 3 steps with 2 images

Blurred answer
Knowledge Booster
Lipids
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Introductory Chemistry: An Active Learning Approa…
Introductory Chemistry: An Active Learning Approa…
Chemistry
ISBN:
9781305079250
Author:
Mark S. Cracolice, Ed Peters
Publisher:
Cengage Learning
EBK A SMALL SCALE APPROACH TO ORGANIC L
EBK A SMALL SCALE APPROACH TO ORGANIC L
Chemistry
ISBN:
9781305446021
Author:
Lampman
Publisher:
CENGAGE LEARNING - CONSIGNMENT
Chemistry for Today: General, Organic, and Bioche…
Chemistry for Today: General, Organic, and Bioche…
Chemistry
ISBN:
9781305960060
Author:
Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:
Cengage Learning
Organic And Biological Chemistry
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
General, Organic, and Biological Chemistry
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning