If 25 mMoles of Lidocaine (MW 234.33, pKa-7.87) is added in a two phase system containing 150 ml of water buffered at pH 7.4 and 150 ml of Octanol. If the partition coefficient of the unionized species (Kd) is 7.77, calculate the overall partition coefficient. The apparant partition cofeeicient at pH 7.4=(1

If 25 mMoles of Lidocaine (MW 234.33, pKa-7.87) is added in a two phase system containing 150 ml of water buffered at pH 7.4 and 150 ml of Octanol. If the partition coefficient of the unionized species (Kd) is 7.77, calculate the overall partition coefficient. The apparant partition cofeeicient at pH 7.4=(1

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter28: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 28.5QAP

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