In a 2017 study examining the efficacy and safety of its use in patients with mild-to-moderate active ulcerative colitis, the KPT drug (figure to the right) was shown to have marked anti- nflammatory properties in preclinical studies and exhibited very ow toxicity in phase I and preclinical trials. Inflamm Bowel Dis. 2017 Feb;23(2):261-271. 3 1] How many ionizable groups are there in KPT? 1] Does the KPT structure, as shown here, predominate at any pH? If so, which pH? If not, why not? H.N. Lost H.N OH OH
In a 2017 study examining the efficacy and safety of its use in patients with mild-to-moderate active ulcerative colitis, the KPT drug (figure to the right) was shown to have marked anti- nflammatory properties in preclinical studies and exhibited very ow toxicity in phase I and preclinical trials. Inflamm Bowel Dis. 2017 Feb;23(2):261-271. 3 1] How many ionizable groups are there in KPT? 1] Does the KPT structure, as shown here, predominate at any pH? If so, which pH? If not, why not? H.N. Lost H.N OH OH
Chapter15: Adult And Pediatric Dosages Based On Body Weight
Section: Chapter Questions
Problem 4.4P
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Does this KPT structure predominate at any pH? If so, which pH? If not, why?
![In a 2017 study examining the efficacy and safety of its use in
patients with mild-to-moderate active ulcerative colitis, the KPT
drug (figure to the right) was shown to have marked anti-
inflammatory properties in preclinical studies and exhibited very
low toxicity in phase I and preclinical trials. Inflamm Bowel
Dis. 2017 Feb;23(2):261-271.
3
[1] How many ionizable groups are there in KPT?
[1] Does the KPT structure, as shown here, predominate at any pH? If so, which pH? If not, why not?
H₂N
kabe
H₂N
base
OH
OH
and](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F92c948e1-a5a6-42ca-a6f6-c7c8dd85ca21%2F566e9200-dfdd-4783-aa91-794daf202105%2Fqzar7ai_processed.jpeg&w=3840&q=75)
Transcribed Image Text:In a 2017 study examining the efficacy and safety of its use in
patients with mild-to-moderate active ulcerative colitis, the KPT
drug (figure to the right) was shown to have marked anti-
inflammatory properties in preclinical studies and exhibited very
low toxicity in phase I and preclinical trials. Inflamm Bowel
Dis. 2017 Feb;23(2):261-271.
3
[1] How many ionizable groups are there in KPT?
[1] Does the KPT structure, as shown here, predominate at any pH? If so, which pH? If not, why not?
H₂N
kabe
H₂N
base
OH
OH
and
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