In a lysosomal storage disease, newly synthesized lysosome hydrolases are secreted from the cells rather than being delivered to the lysosomes. From the list below, what is the most likely reason? Please EXPLAIN. a) The cis-Golgi network lacks a proton gradient b) The ER is unable to produce lysosomal vesicles c) Lysosomal enzymes are not phosphorylated in the rER d) Mannose is not phosphorylated in the cis-Goligi network e) All the hydrolase genes are mutated, resulting in synthesis by ribosomes free in the cytoplasm rather than on the endoplasmic reticulum membrane Give typing answer with explanation and conclusion

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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In a lysosomal storage disease, newly synthesized lysosome hydrolases are secreted from the cells rather than being delivered to the lysosomes. From the list below, what is the most likely reason? Please EXPLAIN.

a) The cis-Golgi network lacks a proton gradient

b) The ER is unable to produce lysosomal vesicles

c) Lysosomal enzymes are not phosphorylated in the rER

d) Mannose is not phosphorylated in the cis-Goligi network

e) All the hydrolase genes are mutated, resulting in synthesis by ribosomes free in the cytoplasm rather than on the endoplasmic reticulum membrane

Give typing answer with explanation and conclusion 

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