In a subunit of a protein, arginine and aspartic acid have an ionic interaction between their side chains.  Part a) If arginine is changed to glutamic acid, would the ionic interaction's stability increase, decrease, or not change and what effect would it have on the protein structure? Explain why. Part b) If arginine is changed to lysine, would the ionic interaction's stability increase, decrease, or not change and what effect would it have on the protein structure? Explain why. Part c) If arginine is changed to isoleucine, would the ionic interaction's stability increase, decrease, or not change and what effect would it have on the protein structure? Explain why.

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter9: Gene Expression And Gene Regulation
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Problem 24QP: a. Can a mutation change a proteins tertiary structure without changing its primary structure? b....
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In a subunit of a protein, arginine and aspartic acid have an ionic interaction between their side chains. 

Part a) If arginine is changed to glutamic acid, would the ionic interaction's stability increase, decrease, or not change and what effect would it have on the protein structure? Explain why.

Part b) If arginine is changed to lysine, would the ionic interaction's stability increase, decrease, or not change and what effect would it have on the protein structure? Explain why.

Part c) If arginine is changed to isoleucine, would the ionic interaction's stability increase, decrease, or not change and what effect would it have on the protein structure? Explain why.

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