In Drosophila, three autosomal genes have the following map 5 m.u. 10 m.u. a b + When a+ b+ c+ abc females are crossed to a bclabc males, how many flies of the phenotype a+ b c+ is expected among 1000 progeny assuming interference of 60%? A) 1 B) 2 C) 5 D) 3 E) 10
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- In Drosophila, three autosomal genes have the following map:20 m.u. 10 m.u.a b ca. Provide the data, in terms of the expected numberof flies in the following phenotypic classes, whena+ b+ c+/ a b c females are crossed to a b c / a b c males. Assume 1000 flies are counted and that nointerference exists in this region.a+ b+ c+a b ca+ b ca b+ c+a+ b+ ca b c+a+ b c+a b+ cb. If the cross was reversed, such that a+ b+ c+ / a b cmales are crossed to a b c / a b c females, howmany flies would you expect in the same phenotypic classes?Homozygous wild-type male mice (AA BB CC) were crossed with triplemutant female mice (aa bb cc), forming an F1 generation with the followinggenotype (Aa Bb Cc). The F1 males were crossed with triple mutantfemales, forming the following F2 phenotypes”“a B c” 3“A b C” 3“a b c” 8“A B c” 5“a b C” 5“A B C” 8“a B C” 6“A b c” 6 44 Determine the sequence of the genesEC1. In drosophila the cw (curly wings) gene and eb (ebony body) genes are found on the same chromosome 20 map units apart. A cross was made between an ebony bodied parental strain and a curly winged parental strain and the F1’s were test crossed. a) What are the genotypes of the parental strains? b) What are the genotypes of the F1’s? c) What is the genotype of the tester strain? d) What progeny phenotypes and genotypes do you expect, and in what proportions? For phenotypes use the mutant phenotype for any that the flies have, and wild-type if they have none. EC2. Here is a tetrad produced by mating a H Y strain to an h y strain. a) What is the tetrad type? b) What has recombined with what? EC3. In corn, a dihybrid for the recessive genes a and b is test-crossed. The distribution of the phenotypes is as follows: A B 122A b 118a B 81a b 79 a) Do the genes appear to be sorting independently? Look at map units here. b) Test your hypothesis with a chi-squared test.
- Miniature wings (Xm) in Drosophila result from an X-linked allele that is recessive to the allele for long wings (X +). Give the genotypes of the parents in each of the following crosses. Male parent Female parent Male offspring Female offspring a. long long 231 long, 250 miniature 560 long 250 miniature b. miniature long 610 long 632 long c. miniature long 410 long, 417 miniature 412 long, 415 miniature 417 miniature 415 miniature d. long miniature 753 miniature 761 long e. long long 625 long 630 longIn Drosophila, a heterozygous female for the X-linkedrecessive traits a, b, and c was crossed to a male that phenotypically expressed a, b, and c. The offspring occurred inthe following phenotypic ratios.+ b c 460a + + 450a b c 32+ + + 38a + c 11+ b + 9 No other phenotypes were observed.(a) Determine the correct sequence and construct amap of these genes on the X chromosome ?In a testcross of a female Drosophila heterozygous for 3 linked, recessive genes the following phenotypes were observed and used to make a map of these genes. Calculate the interference. A---(3.0)---D-----(4.8)-----B A) There is negative interference. B) 1.44 C) 2.08 D) 1 E) 0
- In Drosophila, a heterozygous female for the X-linkedrecessive traits a, b, and c was crossed to a male that phenotypically expressed a, b, and c. The offspring occurred inthe following phenotypic ratios.+ b c 460a + + 450a b c 32+ + + 38a + c 11+ b + 9 No other phenotypes were observed.(a) What progeny phenotypes are missing? Why?Assuming no gene linkage, in a dihybrid cross of AABB x aabb with AaBb F1 heterozygotes, what is the ratio of the F1 gametes (AB, aB, Ab, ab) that will give rise to the F2 offspring? a. 1:1:1:1 b. 1:3:3:1 c. 1:2:2:1 d. 4:3:3:1Almost all calico cats (one is pictured in FIGURE 10.7B) are female. Why? B When this calico cat was an embryo, one of the two X chromosomes was inactivated in each of her cells. The descendants of the cells formed her adult body, which is a mosaic for expression of X chromosome genes. Black fur arises in patches where genes on the X chromosome inherited from one parent are expressed; orange fur arises in patches where genes on the X chromosome inherited from the other parent are expressed. FIGURE 10.7 Animated X chromosome inactivation.
- 5. A strain of Neurospora with genotype A B is crossed with a strain with the genotype a b. Half the progeny are A B and half are a b. Explain how this is possible?64. In Drosophila normal wings are dominant to curly wings. Heterozygotes have normal wings. Pure breeding normal wing males are mated with pure breeding curly wing females; their offspring are then mated. What is the phenotypic ratio in the F2 generation?a. All offspring have curly wingsb. 1 normal wing offspring: 3 curly wing offspringc. 1 normal wing offspring: 1 curly wing offspringd. 3 normal wing offspring: 1 curly wing offspringe. All offspring have normal wings 65. In gel electrophoresis, DNA fragments migrate toward the _______electrode; the _______the fragment, the faster it moves through the gel.a. negative; smallerb. negative; largerc. positive; smallerd. positive; largere. none of the aboveExplain the following: a- No parental type is produced during gametogenesis? b- A dominant wild type produced a sign spot in Drosophila? c- 9:7 phenotypic ratio is produced in dihybrid cross? d- 50% parental type gametes were produced during gametogenesis? e- All recombinant gametes were produced during gametogenesis?