In the chemical synthesis of DNA and RNA, hydroxyl groups are normally converted to triphenylmethyl (trityl) ethers to protect the hydroxyl group from reaction with other reagents. neutralized by the tertiary amine tertiary amine RCH,OH Ph,CCI RCH,OCP., HCI Triphenylmethyl chloride (Trityl chloride) A triphenylmethyl ether (A trityl ether) Triphenylmethyl ethers are stable to aqueous base but are rapidly cleaved in aqueous acid. RCH,OCPH3 + H2O RCH2OH + Ph3COH

In the chemical synthesis of DNA and RNA, hydroxyl groups are normally converted to triphenylmethyl (trityl) ethers to protect the hydroxyl group from reaction with other reagents. neutralized by the tertiary amine tertiary amine RCH,OH Ph,CCI RCH,OCP., HCI Triphenylmethyl chloride (Trityl chloride) A triphenylmethyl ether (A trityl ether) Triphenylmethyl ethers are stable to aqueous base but are rapidly cleaved in aqueous acid. RCH,OCPH3 + H2O RCH2OH + Ph3COH

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

Section22.SE: Something Extra

Problem 63AP: As far back as the 16th century, South American Incas chewed the leaves of the coca bush,...

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